CD68 Antibody (B-7): sc-514937

CD68 Antibody (B-7) is a mouse monoclonal IgG3 antibody that detects CD68 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CD68 is a member of a family of acidic, highly glycosylated lysosomal glycoproteins, which also includes lamp-1 and lamp-2, and plays a crucial role in the immune system. CD68 is primarily located in cytoplasmic granules and the cytoplasm of various non-hematopoietic tissues, such as liver and kidney tubules and glomeruli, as well as on the surface of immune cells like macrophages, monocytes, neutrophils, basophils, and large lymphocytes. CD68 presence on these immune cells serves as a marker for macrophage activation and is involved in the phagocytosis of pathogens and cellular debris, thereby contributing to the body′s defense mechanisms. Additionally, lysosomal glycoproteins like CD68 are essential components of lysosomal membranes, providing structural integrity and protection against degradation by hydrolases, which is vital for maintaining cellular homeostasis and function. Anti-CD68 antibody (B-7) is an invaluable tool for researchers studying immune responses, macrophage biology, and related pathologies.

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CD68 Antibody (B-7) References:

1. Prognostic impact of CD68 and kallikrein 6 in human glioma.  |  Strojnik, T., et al. 2009. Anticancer Res. 29: 3269-79. PMID: 19661345
2. Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.  |  Iqbal, AJ., et al. 2014. Blood. 124: e33-44. PMID: 25030063
3. Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma.  |  Marinaccio, C., et al. 2014. Leuk Res. 38: 1374-7. PMID: 25293515
4. The increase of circulating PD-L1-expressing CD68(+) macrophage in ovarian cancer.  |  Qu, QX., et al. 2016. Tumour Biol. 37: 5031-7. PMID: 26541760
5. Intratumoral and peritumoral expression of CD68 and CD206 in hepatocellular carcinoma and their prognostic value.  |  Ren, CX., et al. 2017. Oncol Rep. 38: 886-898. PMID: 28656201
6. Recruited CD68+CD206+ macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration.  |  Li, H., et al. 2021. Bioact Mater. 6: 1051-1072. PMID: 33102946
7. CD68 and CD83 immune populations in non-metastatic axillary lymph nodes are of prognostic value for the survival and relapse of breast cancer patients.  |  López, C., et al. 2022. Breast Cancer. 29: 618-635. PMID: 35137329
8. Immunoscore Combining CD8, FoxP3, and CD68-Positive Cells Density and Distribution Predicts the Prognosis of Head and Neck Cancer Patients.  |  Furgiuele, S., et al. 2022. Cells. 11: PMID: 35805132
9. Integration of OV6 expression and CD68+ tumor-associated macrophages with clinical features better predicts the prognosis of patients with hepatocellular carcinoma.  |  Wang, MD., et al. 2022. Transl Oncol. 25: 101509. PMID: 36030750
10. Single-cell Sequencing Data Reveals Aggressive CD68-type Macrophages and Prognostic Models in Bladder Cancer.  |  Mao, C. and Xu, N. 2024. Curr Med Chem. 31: 1523-1538. PMID: 37622699

The preferred CD68 antibody is CD68 Antibody (KP1): sc-20060.