CD60b Antibody (UM4D4): sc-32269

CD60b Antibody (UM4D4) is a mouse monoclonal IgM kappa antibody that detects CD60b protein of human origin by immunofluorescence (IF) and flow cytometry (FCM). CD60b (UM4D4) antibody is available in non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. CD60b, also known as CDw60, is a 9-O-acetylated form of the GD3 ganglioside, which plays a crucial role in immune responses. CD60b is predominantly expressed on peripheral blood T cells, monocytes, platelets, synovial fibroblasts, and certain cell lines, highlighting its importance in cellular interactions within the immune system. CD60b is upregulated in cytotoxic T cells, T helper cells, and IL-4-producing cells, suggesting its potential function in providing costimulatory signals that enhance T cell activation and proliferation. This upregulation occurs after the stimulation of naive CD45RA+ T cells, marking their transition to the memory phenotype characterized by CD45RO expression. CD34+ hematopoietic precursor cells have been identified as CD60b positive, indicating its relevance in early immune cell development. Understanding CD60b′s role in T cell activation and expression patterns can provide valuable insights into immune regulation and potential therapeutic targets in various diseases.

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CD60b Antibody (UM4D4) References:

1. CDw 60 antibodies bind to acetylated forms of ganglioside GD3.  |  Kniep, B., et al. 1992. Biochem Biophys Res Commun. 187: 1343-9. PMID: 1417810
2. Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen.  |  Fox, DA., et al. 1990. J Clin Invest. 86: 1124-36. PMID: 2212003
3. Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human 'naive' and 'memory' CD4+ T cells.  |  Semnani, RT., et al. 1994. J Exp Med. 180: 2125-35. PMID: 7525848

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD60b Antibody (UM4D4) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-CD60b Antibody (UM4D4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD60b Antibody (UM4D4) Specifications

Alternate Product Name: CD60b

Product Clone Name: UM4D4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: CD60b

Epitope Species: human

Product Reactivity/Detection: CD60b

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CD60b Antibody (UM4D4): FITC: Fluoroscein, PE: Phycoerythrin