CD6 Antibody (UMCD6/3F7B5): sc-65249

CD6 Antibody (UMCD6/3F7B5) is a mouse monoclonal IgG1 antibody that detects CD6 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD6 is a type I transmembrane glycoprotein predominantly expressed on mature thymocytes, peripheral T cells, and a subset of B cells, playing a crucial role in the immune response. CD6 is located on the cell surface, where CD6 facilitates interactions between thymocytes and thymic epithelial cells, which is essential for T cell development and maturation. CD6 can physically associate with the T cell receptor (TCR)/CD3 complex, enhancing T cell activation and signaling. CD6 presence in brain tissue and association with B cell chronic lymphocytic leukemias further underscores CD6 significance in both normal immune function and disease states. CD6 structural features, including three extracellular scavenger receptor cysteine-rich domains and a cytoplasmic domain that undergoes tyrosine phosphorylation during TCR-mediated activation, contribute to CD6 functional diversity and regulatory roles in immune responses. CD6 (UMCD6/3F7B5) antibody is an invaluable tool for researchers investigating T cell biology and related pathologies.

The preferred CD6 antibody is CD6 Antibody (SPV-L14): sc-7320.