CD57 Antibody (NK-1): sc-6261

CD57 Antibody (NK-1) is a mouse monoclonal IgM kappa antibody that detects CD57 in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD57 (NK-1) antibody is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). CD57 plays a crucial role in the immune system, particularly in the identification and characterization of natural killer (NK) cells and certain T lymphocyte subsets. CD57-positive cells are distinguishable by their granular lymphocyte morphology and significant clonal expansion in patients with conditions such as AIDS and those undergoing bone marrow transplantation. CD57-positive cells have been implicated in the localization to tumor sites, suggesting a potential role in tumor immunity, and are frequently found in elevated numbers within the synovial fluid of patients suffering from rheumatoid arthritis. CD57 (NK-1) monoclonal antibody effectively identifies and characterizes these cells, making this reagent an invaluable tool for researchers studying immune responses and related pathologies.

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CD57 Antibody (NK-1) References:

1. [Phenotypical and functional characterization of leukocytes--the CD-system].  |  Holter, W., et al. 1991. Wien Klin Wochenschr. 103: 247-62. PMID: 2068816
2. CD57 in human natural killer cells and T-lymphocytes.  |  Kared, H., et al. 2016. Cancer Immunol Immunother. 65: 441-52. PMID: 26850637
3. CXCL12-CXCR4 mediates CD57+ CD8+ T cell responses in the progression of type 1 diabetes.  |  Zhong, T., et al. 2024. J Autoimmun. 143: 103171. PMID: 38306953
4. CD4+CD57+ senescent T cells as promoters of systemic lupus erythematosus pathogenesis and the therapeutic potential of senolytic BCL-2 inhibitor.  |  Jiang, J., et al. 2024. Eur J Immunol. 54: e2350603. PMID: 38752316
5. CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.  |  Qi, L., et al. 2024. Br J Cancer. 131: 258-270. PMID: 38834745
6. Marked increase of CD8+S6F1+ and CD8+CD57+ cells in patients with graft-versus-host disease after allogeneic bone marrow transplantation.  |  Fukuda, H., et al. 1994. Bone Marrow Transplant. 13: 181-5. PMID: 7515741
7. CD11/CD18 panel report for swine CD workshop.  |  Kim, YB., et al. 1994. Vet Immunol Immunopathol. 43: 289-91. PMID: 7531911
8. Origin of CD57+ T cells which increase at tumour sites in patients with colorectal cancer.  |  Okada, T., et al. 1995. Clin Exp Immunol. 102: 159-66. PMID: 7554383
9. Leu 7 (CD57) reactivity distinguishes nodular lymphocyte predominance Hodgkin's disease from nodular sclerosing Hodgkin's disease, T-cell-rich B-cell lymphoma and follicular lymphoma.  |  Kamel, OW., et al. 1993. Am J Pathol. 142: 541-6. PMID: 7679553
10. Increased percentage of CD3+, CD57+ lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease.  |  Dupuy d'Angeac, A., et al. 1993. Arthritis Rheum. 36: 608-12. PMID: 7683880
11. Phenotypic properties and cytotoxic functions of human CD8+ cells expressing the CD57 antigen.  |  Yamashita, N., et al. 1993. Nat Immun. 12: 79-91. PMID: 7686417
12. The enigma of CD57+CD28- T cell expansion--anergy or activation?  |  Kern, F., et al. 1996. Clin Exp Immunol. 104: 180-4. PMID: 8603525

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD57 Antibody (NK-1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CD57 Antibody (NK-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD57 Antibody (NK-1) Specifications

Alternate Product Name: CD57

Product Clone Name: NK-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: CD57

Epitope Species: human

Product Reactivity/Detection: CD57

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CD57 Antibody (NK-1): FITC: Fluoroscein, PE: Phycoerythrin