CD53 Antibody (OX44): sc-53055
- CD53 Antibody (OX44) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against T cell blasts of rat origin
- recommended for detection of CD53 a 43kD glycoprotein of mouse and rat origin by IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD53 Antibody (OX44) for IHC(P) applications. These reagents are now offered in bundles with CD53 Antibody (OX44) (see ordering information below).
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CD53 Antibody (OX44) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD53, a 43 kD glycoprotein, in mouse and rat samples through immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-CD53 antibody (OX44) recognizes CD53, a crucial member of the tetraspanin membrane protein family, known for its role in cell activation, signal transduction, and cell adhesion. The tetraspanin superfamily, which includes proteins such as CD9, CD37, CD63, CD81, and CD82, plays a significant role in regulating cell motility and metastasis, acting as a brake on tumor cell movement and thereby contributing to metastasis suppression. CD53 is predominantly expressed on various immune cells, including B cells, monocytes, macrophages, neutrophils, and T cells, highlighting its importance in immune responses. Human neutrophils exhibit high levels of CD53, which is an N-glycosylated pan-leukocyte antigen and the true homolog of the rat MRC-OX-44 antigen. Understanding the expression and function of CD53 is vital for elucidating its role in immune regulation and potential implications in cancer biology, making CD53 monoclonal antibody (OX44) an essential tool for researchers studying these processes.
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CD53 Antibody (OX44) References:
- Association between CD53 genetic polymorphisms and tuberculosis cases. | Jin, HS., et al. 2019. Genes Genomics. 41: 389-395. PMID: 30506122
- The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling. | Greenberg, ZJ., et al. 2020. J Immunol. 204: 58-67. PMID: 31748347
- Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression. | Demaria, MC., et al. 2020. iScience. 23: 101104. PMID: 32428859
- The regulation and function of CD20: an 'enigma' of B-cell biology and targeted therapy. | Pavlasova, G. and Mraz, M. 2020. Haematologica. 105: 1494-1506. PMID: 32482755
- Leukocyte Tetraspanin CD53 Restrains α3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. | Yeung, L., et al. 2020. J Immunol. 205: 521-532. PMID: 32532837
- Exploring the Pathogenesis of Psoriasis Complicated With Atherosclerosis via Microarray Data Analysis. | Su, W., et al. 2021. Front Immunol. 12: 667690. PMID: 34122426
- Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice. | Yeung, L., et al. 2021. Immunol Cell Biol. 99: 1053-1066. PMID: 34514627
- Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function. | Dunlock, VE., et al. 2022. Cell Rep. 39: 111006. PMID: 35767951
- The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex-mediated quiescence. | Greenberg, ZJ., et al. 2023. Blood. 141: 1180-1193. PMID: 36542833
- PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation. | Kar, P., et al. 2024. EMBO J. 43: 2929-2953. PMID: 38834853
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD53 Antibody (OX44) | sc-53055 | 200 µg/ml | $316.00 | |||
CD53 Antibody (OX44): m-IgG Fc BP-HRP Bundle | sc-538970 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD53 Antibody (OX44): m-IgG1 BP-HRP Bundle | sc-541185 | 200 µg Ab; 20 µg BP | $354.00 | |||
CD53 Antibody (OX44) FITC | sc-53055 FITC | 200 µg/ml | $330.00 | |||
CD53 Antibody (OX44) PE | sc-53055 PE | 200 µg/ml | $343.00 |