CD53 Antibody (HD77): sc-73365

CD53 Antibody (HD77) is a mouse monoclonal IgG1 antibody that detects CD53 in human samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD53 is a crucial member of the tetraspanin family of membrane proteins, which play significant roles in cell activation, signal transduction, and cell adhesion. CD53 is predominantly expressed in the lymphoid-myeloid lineage, including high levels in human neutrophils, and serves as a pan-leukocyte antigen. CD53 is involved in regulating cell motility and has been identified as a metastasis suppressor, acting as a brake on tumor cell movement. CD53′s structure, characterized by four transmembrane domains, allows interaction with various other proteins, facilitating the formation of signaling complexes essential for immune responses. CD53′s ability to modulate cell behavior highlights its importance in both normal immune function and cancer pathology, making anti-CD53 antibody (HD77) an invaluable tool for researchers studying these processes.

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CD53 Antibody (HD77) References:

1. Identifying RBM47, HCK, CD53, TYROBP, and HAVCR2 as Hub Genes in Advanced Atherosclerotic Plaques by Network-Based Analysis and Validation.  |  Liu, C., et al. 2020. Front Genet. 11: 602908. PMID: 33519905
2. Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesis.  |  Sun, S., et al. 2021. Blood. 138: 1211-1224. PMID: 34115843
3. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.  |  Ferguson, ID., et al. 2022. Nat Commun. 13: 4121. PMID: 35840578
4. M2 macrophage-related gene signature in chronic rhinosinusitis with nasal polyps.  |  Zhu, Y., et al. 2022. Front Immunol. 13: 1047930. PMID: 36466903
5. GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy.  |  Li, X., et al. 2023. Front Immunol. 14: 1127612. PMID: 37622120
6. Single-cell transcriptome analysis reveals the key genes associated with macrophage polarization in liver cancer.  |  Ding, Z., et al. 2023. Hepatol Commun. 7: PMID: 37889536
7. N-Glycosylation-dependent regulation of immune-specific tetraspanins CD37 and CD53.  |  van Deventer, S., et al. 2024. Biophys J. 123: 2301-2311. PMID: 38031400
8. Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.  |  Chakraborty, M., et al. 2024. J Immunol. 212: 1075-1080. PMID: 38363205
9. The conformation of tetraspanins CD53 and CD81 differentially affects their nanoscale organization and interaction with their partners.  |  Schwerdtfeger, F., et al. 2024. J Biol Chem. 300: 107685. PMID: 39159818
10. Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation.  |  Hsu, AT., et al. 2024. Allergy.. PMID: 39651606

The preferred CD53 antibody is CD53 Antibody (B-12): sc-390185.