CD5 Antibody (HK231): sc-69734

CD5 Antibody (HK231) is a mouse monoclonal IgG1 antibody that detects CD5 in human samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD5 is a crucial transmembrane glycoprotein predominantly expressed on T lymphocytes, where CD5 plays a significant role in modulating T cell activation and signaling. Located on the surface of these immune cells, CD5 interacts with the T cell receptor (TCR) and the CD3 complex, influencing T cell responses to antigens. Notably, the binding of CD5 to CD72 is believed to be involved in the regulation of T cell activation and thymic selection, although the precise mechanisms remain an area of active research. The phosphorylation of CD5 upon TCR engagement enhances the activity of the Src family kinase Lck, which is critical for T cell signaling. CD5′s ability to fine-tune T cell responses underscores CD5′s importance in maintaining immune homeostasis and preventing overactive immune responses, making anti-CD5 antibody (HK231) an essential tool for researchers studying T cell biology and related immunological processes.

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The preferred CD5 antibody is CD5 Antibody (UCH-T2): sc-1180.