CD5 Antibody (CC17): sc-59085

CD5 Antibody (CC17) is a mouse monoclonal IgG1 antibody that detects CD5 in bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD5 is a crucial transmembrane glycoprotein predominantly expressed on T lymphocytes, where CD5 plays a significant role in modulating T cell activation and signaling. Located on the surface of these immune cells, CD5 interacts with the T cell receptor (TCR) and the CD3 complex, influencing the strength and duration of T cell responses. Notably, the binding of CD5 to CD72 is believed to be involved in the thymic selection process, although the exact consequences of this interaction remain an area of active research. The phosphorylation of CD5 upon TCR engagement enhances the activity of the Src family kinase Lck, leading to a more regulated immune response. The importance of CD5 in maintaining T cell homeostasis and preventing hyper-responsiveness underscores CD5′s potential as a target for therapeutic interventions in immune-related disorders. Anti-CD5 antibody (CC17) is an essential tool for researchers studying T cell biology and the intricate mechanisms of immune regulation in bovine models.

The preferred CD5 antibody is CD5 Antibody (UCH-T2): sc-1180.