CD48 Antibody (OX46): sc-53052
- CD48 Antibody (OX46) is a mouse monoclonal IgG2a provided at 200 µg/ml
- raised against T blasts from a mixed lymphocyte reaction of rat origin
- recommended for detection of CD48 glycoprotein on all heamatopoietic cells of mouse and rat origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD48 Antibody (OX46). This work is in progress.
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CD48 Antibody (OX46) is a mouse monoclonal IgG2a antibody that detects CD48 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD48 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that plays a crucial role in immune responses by acting as a low-affinity receptor for CD2, facilitating interactions between T cells and antigen-presenting cells. CD48 expression on various immune cells, including T, B, and null cells, as well as thymocytes and eosinophils, underscores CD48′s importance in modulating immune cell activation and proliferation. CD48 associates with the tyrosine kinase Lck, which is vital for T cell receptor signaling, thereby influencing T cell development and function. CD48 expression on hematopoietic and endothelial cells in rats, and on thymocytes and macrophages in mice, highlights CD48′s significance in both adaptive and innate immunity. Anti-CD48 antibody (OX46) is an essential tool for researchers aiming to explore the intricate mechanisms of immune regulation and cell signaling pathways.
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CD48 Antibody (OX46) References:
- CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. | Kato, K., et al. 1992. J Exp Med. 176: 1241-9. PMID: 1383383
- CD2-CD48 interactions promote interleukin-2 and interferon-gamma synthesis by stabilizing cytokine mRNA. | Musgrave, BL., et al. 2004. Cell Immunol. 229: 1-12. PMID: 15331323
- Serum Soluble CD48 Levels as a Prognostic Marker in Mycosis Fungoides and Sézary Syndrome. | Oka, T., et al. 2018. J Invest Dermatol. 138: 2286-2288. PMID: 29605670
- The oncogenic fusion protein CBFB-SMMHC downregulates CD48 to evade NK cell recognition. | Kahlon, S., et al. 2018. Blood Cancer J. 8: 48. PMID: 29795444
- CD48 and α7 Nicotinic Acetylcholine Receptor Synergistically Regulate FimH-Mediated Escherichia coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells. | Liu, R., et al. 2019. J Infect Dis. 219: 470-479. PMID: 30202861
- Recurrent inflammatory disease caused by a heterozygous mutation in CD48. | Volkmer, B., et al. 2019. J Allergy Clin Immunol. 144: 1441-1445.e17. PMID: 31419545
- Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. | Van Laethem, F., et al. 2020. Front Immunol. 11: 1216. PMID: 32612609
- Heme oxygenase 1 overexpression induces immune evasion of acute myeloid leukemia against natural killer cells by inhibiting CD48. | Zhang, T., et al. 2022. J Transl Med. 20: 394. PMID: 36058936
- Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked co-receptor CD48 reveals a novel mechanism to modulate PD-1-dependent inhibition of human T cells. | White, D., et al. 2023. Mol Immunol. 156: 31-38. PMID: 36889184
- CD48 binds to heparan sulfate on the surface of epithelial cells. | Ianelli, CJ., et al. 1998. J Biol Chem. 273: 23367-75. PMID: 9722571
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD48 Antibody (OX46) | sc-53052 | 200 µg/ml | $322.00 | |||
CD48 Antibody (OX46) FITC | sc-53052 FITC | 200 µg/ml | $336.00 | |||
CD48 Antibody (OX46) PE | sc-53052 PE | 200 µg/ml | $349.00 |