CD48 Antibody (MEM-102): sc-51558
- CD48 Antibody (MEM-102) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against Burkitt's lymphoma human cell line Raji
- recommended for detection of CD48 of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD48 Antibody (MEM-102). This work is in progress.
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CD48 Antibody (MEM-102) is a mouse monoclonal IgG1 antibody that detects CD48 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD48 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that plays a crucial role in immune responses by acting as a low-affinity receptor for CD2, facilitating cell-cell interactions essential for T cell activation and proliferation. CD48 expression occurs on all peripheral blood T, B, and null cells, as well as on thymocytes and eosinophils, underscoring CD48′s importance in the immune system, particularly in lymphocyte activation and differentiation. CD48 expression extends to various cell types, including hematopoietic and endothelial cells in rats, and on thymocytes, lymph node cells, most macrophages, and bone marrow cells in mice, highlighting CD48′s conserved function across species. CD48 associates with tyrosine kinase Lck, which is vital for T cell receptor signaling, further emphasizing CD48′s significance in modulating immune responses.
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CD48 Antibody (MEM-102) References:
- Distinctive lack of CD48 expression in subsets of human dendritic cells tunes NK cell activation. | Morandi, B., et al. 2005. J Immunol. 175: 3690-7. PMID: 16148114
- CD48 is critically involved in allergic eosinophilic airway inflammation. | Munitz, A., et al. 2007. Am J Respir Crit Care Med. 175: 911-8. PMID: 17290046
- Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. | Muhammad, A., et al. 2009. J Immunol. 182: 7672-80. PMID: 19494291
- CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. | Boles, NC., et al. 2011. Blood. 118: 80-7. PMID: 21576698
- A Novel CD48-Based Analysis of Sepsis-Induced Mouse Myeloid-Derived Suppressor Cell Compartments. | Jia, B., et al. 2017. Mediators Inflamm. 2017: 7521701. PMID: 28337051
- Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family. | Martínez-Vicente, P., et al. 2020. Viruses. 12: PMID: 32731344
- Elevated Serum Level of CD48 in Patients with Intermittent Allergic Rhinitis. | Branicka, O., et al. 2021. Int Arch Allergy Immunol. 182: 39-48. PMID: 32966985
- Human innate lymphoid cell precursors express CD48 that modulates ILC differentiation through 2B4 signaling. | Tufa, DM., et al. 2020. Sci Immunol. 5: PMID: 33219153
- Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease. | Kim, SH., et al. 2023. FASEB J. 37: e22702. PMID: 36520044
- CD48 delivers an accessory signal for CD40-mediated activation of human B cells. | Klyushnenkova, EN., et al. 1996. Cell Immunol. 174: 90-8. PMID: 8929458
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD48 Antibody (MEM-102) | sc-51558 | 100 µg/ml | $322.00 |