CD48 Antibody (HM48-1): sc-19666
- CD48 Antibody (HM48-1) is a Armenian hamster monoclonal IgG, cited in 1 publications, provided at 200 µg/ml
- recommended for detection of CD48 of mouse and rat origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD48 Antibody (HM48-1). This work is in progress.
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CD48 Antibody (HM48-1) is a hamster monoclonal IgG antibody that detects CD48 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD48 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that plays a crucial role in immune responses by acting as a low-affinity receptor for CD2, facilitating cell-cell interactions essential for T cell activation and proliferation. CD48 expression occurs on various immune cells, including T, B, and null cells, as well as thymocytes and eosinophils, underscoring CD48′s importance in modulating immune responses. CD48 is expressed on hematopoietic and endothelial cells in rats and is found on thymocytes, lymph node cells, and most macrophages in mice, highlighting CD48′s widespread involvement in the immune system. CD48 has been shown to associate with the tyrosine kinase Lck, which is vital for T cell receptor signaling, further emphasizing CD48′s significance in immune regulation and potential therapeutic targeting in immune-related diseases.
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CD48 Antibody (HM48-1) References:
- CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. | Abadía-Molina, AC., et al. 2006. Gastroenterology. 130: 424-34. PMID: 16472597
- Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. | Milstein, O., et al. 2008. J Biol Chem. 283: 34414-22. PMID: 18826951
- CD48 as a novel molecular target for antibody therapy in multiple myeloma. | Hosen, N., et al. 2012. Br J Haematol. 156: 213-24. PMID: 22098460
- CD48 on blood leukocytes and in serum of asthma patients varies with severity. | Gangwar, RS., et al. 2017. Allergy. 72: 888-895. PMID: 27859399
- Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor. | Martínez-Vicente, P., et al. 2019. PLoS Pathog. 15: e1007658. PMID: 30947296
- Acute myeloid leukemia immune escape by epigenetic CD48 silencing. | Wang, Z., et al. 2020. Clin Sci (Lond). 134: 261-271. PMID: 31922199
- Genome-wide CRISPR screens identify CD48 defining susceptibility to NK cytotoxicity in peripheral T-cell lymphomas. | Chiba, M., et al. 2022. Blood. 140: 1951-1963. PMID: 35921533
- CD48 suppresses proliferation and migration as an immune-related prognostic signature in the cervical cancer immune microenvironment. | Ma, Y., et al. 2024. Carcinogenesis. 45: 57-68. PMID: 37279525
- Eradication of CD48-positive tumors by selectively enhanced YTS cells harnessing the lncRNA NeST. | Kotzur, R., et al. 2023. iScience. 26: 107284. PMID: 37609636
- A Systematic Immune and Prognostic Analysis of CD48 Interaction with Tumor Microenvironment in Pan-Cancer. | He, M., et al. 2023. Int J Gen Med. 16: 5255-5269. PMID: 38021043
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD48 Antibody (HM48-1) | sc-19666 | 200 µg/ml | $322.00 | |||
CD48 Antibody (HM48-1) FITC | sc-19666 FITC | 200 µg/ml | $336.00 | |||
CD48 Antibody (HM48-1) PE | sc-19666 PE | 200 µg/ml | $349.00 |