CD43 Antibody (0.N.117): sc-70681

CD43 Antibody (0.N.117) is a mouse monoclonal IgG1 antibody that detects CD43 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD43, also known as leukosialin, is a major O-glycosylated sialoglycoprotein predominantly found on the surface of leukocytes, where CD43 plays a crucial role in cellular adhesion and immune response modulation. CD43 is a member of the surface mucin family and is characterized by extensive glycosylation, which is essential for CD43′s function in regulating cell-cell interactions and maintaining the integrity of the immune system. The structure of CD43, featuring a large extracellular domain, allows CD43 to interact with various ligands and other cell surface proteins, influencing processes such as T cell activation and migration. Understanding the structural properties of CD43 is vital, as alterations in CD43 expression or function can lead to immune dysregulation and contribute to the progression of certain hematological malignancies. CD43 monoclonal antibody (0.N.117) is therefore an invaluable tool for researchers studying immune cell dynamics and the role of this important glycoprotein in both normal physiology and disease states.

The preferred CD43 antibody is CD43 Antibody (DF-T1): sc-6256.