CD36 Antibody (5K65): sc-70644

CD36 Antibody (5K65) is a mouse monoclonal IgM kappa light chain antibody developed to detect CD36, also known as platelet glycoprotein 4 (GPIV), fatty acid translocase (FAT), glycoprotein IIIb (GPIIIB), scavenger receptor class B member 3 (SCARB3), and PAS IV. CD36 is a multifunctional membrane glycoprotein prominently expressed on platelets, monocytes, and umbilical vein endothelial cells, where CD36 plays a crucial role in binding to ligands like collagen, thrombospondin, anionic phospholipids, and oxidized low-density lipoproteins (LDL). CD36 undergoes various post-translational modifications, including glycosylation and phosphorylation, which are essential for stability, localization, and ability to mediate signaling pathways involved in phagocytosis, lipid metabolism, and cell adhesion. These modifications are vital for maintaining cellular homeostasis and enabling CD36 to participate effectively in processes such as the continuous production of mature spermatozoa and the regulation of inflammatory responses. Additionally, CD36 functions as a key cell adhesion molecule, influencing adhesive interactions that are important for tissue integrity and repair. Mutations in the CD36 gene can lead to platelet glycoprotein deficiency, highlighting CD36′s significance in normal platelet function and hemostasis. Anti-CD36 antibody (5K65) is reactive across mouse, rat, and human species, and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). By enabling accurate detection and analysis of CD36 and post-translational modifications, CD36 (5K65) antibody supports advanced research into CD36′s diverse roles in cardiovascular diseases, metabolic disorders, and immune system regulation.

The preferred CD36 antibody is CD36 Antibody (SMφ): sc-7309.