CD23 Antibody (HD50): sc-18910

CD23 Antibody (HD50) is a mouse monoclonal IgG2b antibody that detects CD23 in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD23, also known as the human leukocyte differentiation antigen FCE2, is a type II integral membrane glycoprotein predominantly expressed on mature B cells, monocytes, eosinophils, platelets, and dendritic cells, playing a crucial role in the immune response. CD23 functions as a low-affinity IgE receptor, facilitating IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils, which is vital for the body′s defense against parasitic infections and allergic reactions. CD23 forms oligomers, requiring cooperative binding of at least two lectin domains for high-affinity IgE binding, and is implicated in antigen presentation by B cells through interaction with CD40. Additionally, CD23 is associated with the Fyn tyrosine kinase, and CD23′s truncated form can be secreted to act as a potent mitogenic growth factor. The ectodomain shedding of CD23 is catalyzed by proteins such as ADAM8, ADAM15, and MDC-L, highlighting CD23′s dynamic role in immune regulation. Notably, intestinal cells express both CD23a and CD23b splice forms, which exhibit different localizations in polarized cells, further emphasizing the complexity and significance of CD23 in immune function.

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CD23 Antibody (HD50) References:

1. CD23 provides a noninflammatory pathway for IgE-allergen complexes.  |  Engeroff, P., et al. 2020. J Allergy Clin Immunol. 145: 301-311.e4. PMID: 31437490
2. CD23 is a glycan-binding receptor in some mammalian species.  |  Jégouzo, SAF., et al. 2019. J Biol Chem. 294: 14845-14859. PMID: 31488546
3. The role of CD23 in the regulation of allergic responses.  |  Engeroff, P. and Vogel, M. 2021. Allergy. 76: 1981-1989. PMID: 33378583
4. Increased CD23 expression in postsplenectomy polyclonal B-Cell lymphocytosis.  |  Mehdipour Dalivand, M., et al. 2022. Int J Lab Hematol. 44: e32-e35. PMID: 34448336
5. Overlap between CD23 and CD200 in leukemic lymphoproliferative disorders.  |  Güell, N., et al. 2022. Int J Lab Hematol. 44: e149-e152. PMID: 35000272
6. Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.  |  Zhang, N., et al. 2022. J Immunol. 208: 827-838. PMID: 35046106
7. Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia.  |  Tettamanti, S., et al. 2022. Leuk Lymphoma. 63: 1566-1579. PMID: 35259043
8. IgE-neutralizing UB-221 mAb, distinct from omalizumab and ligelizumab, exhibits CD23-mediated IgE downregulation and relieves urticaria symptoms.  |  Kuo, BS., et al. 2022. J Clin Invest. 132: PMID: 35912861
9. The expression of CD200 and CD23 on B lymphocytes in the pollen season and outside the pollen season in atopic dermatitis patients with and without dupilumab therapy.  |  Čelakovská, J., et al. 2024. J Dermatolog Treat. 35: 2305832. PMID: 38263709
10. CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy.  |  Ota, M., et al. 2024. Sci Transl Med. 16: eadi0673. PMID: 38324641

The preferred CD23 antibody is CD23 Antibody (BU38): sc-58995.