CD223 Antibody (C9B7W): sc-32750
- CD223 Antibody (C9B7W) is a rat monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against a fusion protein consisting of CD223 of mouse CD223 with mouse IgG1 and recognizes an epitope in the D2 domain of CD223
- recommended for detection of CD223 of mouse origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD223 Antibody (C9B7W). This work is in progress.
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SEE ALSO...
CD223 (C9B7W) is a rat monoclonal IgG1 antibody. CD223 (Lymphocyte activation gene-3, LAG-3) functions as a high affinity MHC class II ligand present on CD4(+)CD8(+) T cells and NK cells. CD223 shares structural homology with CD4 molecules, featuring four similar extracellular Ig-like domains and structural motifs between D1-D3 and D2-D4 domains. A glutamic acid-proline (EP) repetitive sequence found in CD223 appears in other functionally distinct mammalian, parasitic, and bacterial proteins, suggesting influence on a conserved biological function. CD223(+)CD4(+)CD8(+) T cells associate with T cell receptor (TCR) and downregulate TCR signaling in vitro. CD223 regulates CD4-dependent T cell function through its cytoplasmic domain. A conserved "KIEELE" motif containing Lys-468 in CD223 plays an essential role in interactions with downstream signaling molecules.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD223 Antibody (C9B7W) | sc-32750 | 200 µg/ml | $322.00 | |||
CD223 Antibody (C9B7W) FITC | sc-32750 FITC | 200 µg/ml | $336.00 | |||
CD223 Antibody (C9B7W) PE | sc-32750 PE | 200 µg/ml | $349.00 |