CD1D Antibody (C3D5): sc-19632

CD1D Antibody (C3D5) is a mouse monoclonal IgG2a kappa light chain antibody that detects the CD1D protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CD1D antibody (C3D5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The CD1 multigene family encodes five forms of the CD1 T cell surface glycoprotein in humans, which are CD1A, CD1B, CD1C, CD1D, and CD1E. CD1D plays a crucial role in the immune system by presenting lipid antigens to T lymphocytes, thereby influencing T cell activation and maturation. CD1D is primarily located on the surface of human intestinal epithelial cells and is known to exist in two forms: a β-2-Microglobulin-independent nonglycosylated form and a β-2-Microglobulin-dependent glycosylated form. CD1D expression on these cells facilitates the recognition of lipid antigens, which is essential for the immune response against various pathogens. Additionally, CD1D is associated with β-2-Microglobulin and is expressed on cortical thymocytes, Langerhans cells, a subset of B cells, and certain dendritic cells, highlighting its importance in the development and activation of CD1-restricted T cells. The human CD1D gene is located on chromosome 1q23.1 and encodes a 335 amino acid protein that is vital for normal T cell maturation, making CD1D (C3D5) monoclonal antibody an essential tool for researchers studying immune responses and T cell biology.

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CD1D Antibody (C3D5) References:

1. Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis.  |  Kim, HS., et al. 2000. Mol Immunol. 37: 861-8. PMID: 11257307
2. CD1d and natural T cells: how their properties jump-start the immune system.  |  Joyce, S. 2001. Cell Mol Life Sci. 58: 442-69. PMID: 11315191
3. The identification of the beta 2-microglobulin binding antigen encoded by the human CD1D gene.  |  Bilsland, CA. and Milstein, C. 1991. Eur J Immunol. 21: 71-8. PMID: 1703966
4. Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule.  |  Balk, SP., et al. 1989. Proc Natl Acad Sci U S A. 86: 252-6. PMID: 2463622
5. Two classes of CD1 genes.  |  Calabi, F., et al. 1989. Eur J Immunol. 19: 285-92. PMID: 2467814
6. Lipids regulate peripheral serotonin release via gut CD1d.  |  Luo, J., et al. 2023. Immunity. 56: 1533-1547.e7. PMID: 37354904
7. Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions.  |  Lameris, R., et al. 2023. J Immunother Cancer. 11: PMID: 38040419
8. CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis.  |  Lei, Z., et al. 2024. J Hepatol. 80: 194-208. PMID: 38438948
9. The CD1 family: a third lineage of antigen-presenting molecules.  |  Porcelli, SA. 1995. Adv Immunol. 59: 1-98. PMID: 7484459
10. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium.  |  Balk, SP., et al. 1994. Science. 265: 259-62. PMID: 7517575
11. Antigen presentation by CD1 and MHC-encoded class I-like molecules.  |  Melián, A., et al. 1996. Curr Opin Immunol. 8: 82-8. PMID: 8729450
12. Analysis of the requirement for beta 2-microglobulin for expression and formation of human CD1 antigens.  |  Bauer, A., et al. 1997. Eur J Immunol. 27: 1366-73. PMID: 9209486

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD1D Antibody (C3D5) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-CD1D Antibody (C3D5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD1D Antibody (C3D5) Specifications

Alternate Product Name: CD1D

Product Clone Name: C3D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: CD1D

Epitope Species: human

Product Reactivity/Detection: an epitope in the α 1 domain of CD1D

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for CD1D Antibody (C3D5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin