CD1C Antibody (B-6): sc-390980
- CD1C Antibody (B-6) is a mouse monoclonal IgG1 κ CD1C antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 74-118 mapping within an internal region of CD1C of human origin
- CD1C Antibody (B-6) is recommended for detection of CD1C of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CD1C Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD1C Antibody (B-6) for WB applications. These reagents are now offered in bundles with CD1C Antibody (B-6) (see ordering information below).
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CD1C Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD1C of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD1C (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. CD1C plays a crucial role in the immune system as a member of the CD1 multigene family, which encodes five forms of the CD1 T-cell surface glycoprotein in humans, namely CD1A, CD1B, CD1C, CD1D, and CD1E. These proteins are essential for presenting lipid antigens to T lymphocytes, thereby facilitating the recognition of lipid-based pathogens and contributing to the adaptive immune response. CD1C is expressed on various immune cells, including cortical thymocytes and dendritic cells, and is involved in the development and activation of CD1-restricted T cells. Proper functioning of CD1C is vital for maintaining immune homeostasis and responding to infections, making CD1C an important target for research in immunology and potential therapeutic applications. Human CD1 genes are closely linked in a cluster located at chromosome 1q 22-23, highlighting their evolutionary significance and functional interdependence.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD1C Antibody (B-6) References:
- New insights into pathways for CD1-mediated antigen presentation. | Sugita, M., et al. 2004. Curr Opin Immunol. 16: 90-5. PMID: 14734115
- CD1: antigen presentation and T cell function. | Brigl, M. and Brenner, MB. 2004. Annu Rev Immunol. 22: 817-90. PMID: 15032598
- Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. | Martin, LH., et al. 1987. Proc Natl Acad Sci U S A. 84: 9189-93. PMID: 2447586
- Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. | Aruffo, A. and Seed, B. 1989. J Immunol. 143: 1723-30. PMID: 2701945
- Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. | Longley, J., et al. 1989. J Invest Dermatol. 92: 628-31. PMID: 2784820
- The CD1 family: a third lineage of antigen-presenting molecules. | Porcelli, SA. 1995. Adv Immunol. 59: 1-98. PMID: 7484459
- Surface antigens of human thymocyte populations defined by CD3, CD4 and CD8 expression: CD1a is expressed by mature thymocytes but not peripheral T cells. | Sotzik, F., et al. 1993. Immunol Lett. 36: 101-6. PMID: 7688345
- Class I-like CD1A-C do not protect target cells from NK-mediated cytolysis. | Storkus, WJ., et al. 1996. Cell Immunol. 167: 154-6. PMID: 8548840
- Antigen presentation by CD1 and MHC-encoded class I-like molecules. | Melián, A., et al. 1996. Curr Opin Immunol. 8: 82-8. PMID: 8729450
- Analysis of the requirement for beta 2-microglobulin for expression and formation of human CD1 antigens. | Bauer, A., et al. 1997. Eur J Immunol. 27: 1366-73. PMID: 9209486
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD1C Antibody (B-6) | sc-390980 | 200 µg/ml | $316.00 | |||
CD1C Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-530324 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD1C Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-523762 | 200 µg Ab, 40 µg BP | $354.00 | |||
CD1C Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-543990 | 200 µg Ab; 20 µg BP | $354.00 | |||
CD1C Antibody (B-6) AC | sc-390980 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CD1C Antibody (B-6) HRP | sc-390980 HRP | 200 µg/ml | $316.00 | |||
CD1C Antibody (B-6) FITC | sc-390980 FITC | 200 µg/ml | $330.00 | |||
CD1C Antibody (B-6) PE | sc-390980 PE | 200 µg/ml | $343.00 | |||
CD1C Antibody (B-6) Alexa Fluor® 488 | sc-390980 AF488 | 200 µg/ml | $357.00 | |||
CD1C Antibody (B-6) Alexa Fluor® 546 | sc-390980 AF546 | 200 µg/ml | $357.00 | |||
CD1C Antibody (B-6) Alexa Fluor® 594 | sc-390980 AF594 | 200 µg/ml | $357.00 | |||
CD1C Antibody (B-6) Alexa Fluor® 647 | sc-390980 AF647 | 200 µg/ml | $357.00 | |||
CD1C Antibody (B-6) Alexa Fluor® 680 | sc-390980 AF680 | 200 µg/ml | $357.00 | |||
CD1C Antibody (B-6) Alexa Fluor® 790 | sc-390980 AF790 | 200 µg/ml | $357.00 |