CD165 Antibody (AD2): sc-53885
- CD165 Antibody (AD2) is a mouse monoclonal IgG1 κ CD165 antibody provided at 200 µg/ml
- raised against HSB cells of human origin
- CD165 Antibody (AD2) is recommended for detection of CD165 of human origin by WB, IP, IF and FCM
- Anti-CD165 Antibody (AD2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD165 Antibody (AD2) for WB applications. These reagents are now offered in bundles with CD165 Antibody (AD2) (see ordering information below).
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CD165 Antibody (AD2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD165 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD165 (AD2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD165, also known as AD2, is a cell surface glycoprotein that plays a crucial role in the immune system, particularly in interactions between T cells and thymic epithelial cells, which are essential for normal T cell development. CD165 is predominantly localized to the membrane of a specific subset of peripheral lymphocytes and monocytes, with strong expression observed in T-cell type acute lymphoblastic leukemia and nearly all platelets. CD165 is found in various tissues, including the spleen, thymus, central nervous system neurons, pancreatic islet cells, and Bowman′s capsule of the kidney. CD165 functions as an adhesion molecule, facilitating the binding of thymocytes to thymic epithelial cells, which is vital for the maturation and differentiation of T cells. Understanding CD165′s role in these processes can provide insights into immune responses and potential therapeutic targets for inflammatory skin diseases and cutaneous T cell malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD165 Antibody (AD2) References:
- Cross-reactivity with bovine cells of monoclonal antibodies submitted to the 6th International Workshop on Human Leukocyte Differentiation Antigens. | Sopp, P., et al. 2001. Vet Immunol Immunopathol. 78: 197-206. PMID: 11182157
- Antigenic profile of human thymus in concurrence with 'Clusters of Thymic Epithelial Staining' classification. | Kaymaz, FF., et al. 2003. Ann Anat. 185: 163-71. PMID: 12725440
- Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. | Serebruany, VL., et al. 2004. Thromb Res. 113: 197-204. PMID: 15140583
- Escitalopram, but not its major metabolites, exhibits antiplatelet activity in humans. | Atar, D., et al. 2006. J Clin Psychopharmacol. 26: 172-7. PMID: 16633147
- AD2, a human molecule involved in the interaction of T cells with epidermal keratinocytes and thymic epithelial cells. | Bruggers, CS., et al. 1995. J Immunol. 154: 2012-22. PMID: 7868879
- The cytogenetics of 90 patients with idiopathic mental retardation/malformation syndromes and of 90 normal subjects. | Doyle, CT. 1976. Hum Genet. 33: 131-46. PMID: 939565
- Phenotypic mapping of human mesothelial cells. | Ross, JA., et al. 1998. Adv Perit Dial. 14: 25-30. PMID: 10649685
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD165 Antibody (AD2) | sc-53885 | 200 µg/ml | $322.00 | |||
CD165 Antibody (AD2): m-IgG Fc BP-HRP Bundle | sc-526846 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD165 Antibody (AD2): m-IgG1 BP-HRP Bundle | sc-532219 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD165 Antibody (AD2) AC | sc-53885 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD165 Antibody (AD2) HRP | sc-53885 HRP | 200 µg/ml | $322.00 | |||
CD165 Antibody (AD2) FITC | sc-53885 FITC | 200 µg/ml | $336.00 | |||
CD165 Antibody (AD2) PE | sc-53885 PE | 200 µg/ml | $349.00 | |||
CD165 Antibody (AD2) Alexa Fluor® 488 | sc-53885 AF488 | 200 µg/ml | $364.00 | |||
CD165 Antibody (AD2) Alexa Fluor® 546 | sc-53885 AF546 | 200 µg/ml | $364.00 | |||
CD165 Antibody (AD2) Alexa Fluor® 594 | sc-53885 AF594 | 200 µg/ml | $364.00 | |||
CD165 Antibody (AD2) Alexa Fluor® 647 | sc-53885 AF647 | 200 µg/ml | $364.00 | |||
CD165 Antibody (AD2) Alexa Fluor® 680 | sc-53885 AF680 | 200 µg/ml | $364.00 | |||
CD165 Antibody (AD2) Alexa Fluor® 790 | sc-53885 AF790 | 200 µg/ml | $364.00 |