CD15 Antibody (TG-1): sc-19595

CD15 Antibody (TG-1) is a mouse monoclonal IgM antibody that detects CD15 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD15, also known as Lewis X or LeX, is a crucial carbohydrate antigen synthesized by FucT-IV (alpha 1,3-fucosyltransferase IV), which catalyzes the addition of fucose to sugar acceptor molecules, resulting in the formation of a trisaccharide prominently displayed on leukocytes and certain tumor cells. CD15 on cell surfaces is vital for mediating cell adhesion, acting as an adhesion molecule that facilitates calcium-dependent homotypic binding, leading to strong self-aggregation of cells expressing high CD15 levels in the presence of calcium ions. Furthermore, CD15 serves as a ligand for selectins, essential proteins involved in leukocyte trafficking and interactions, highlighting CD15′s significant role in immune responses and cellular communication. Anti-CD15 antibody (TG-1) is an invaluable tool for researchers investigating cell adhesion dynamics and CD15′s functional implications in various physiological and pathological contexts.

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CD15 Antibody (TG-1) References:

1. CD15 immunoreactive amacrine cells in the mouse retina.  |  Jakobs, TC., et al. 2003. J Comp Neurol. 465: 361-71. PMID: 12966561
2. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity.  |  Gadhoum, SZ. and Sackstein, R. 2008. Nat Chem Biol. 4: 751-7. PMID: 18953356
3. Transient CD15-positive endothelial phenotype in the human placenta correlates with physiological and pathological fetoplacental immaturity.  |  Seidmann, L., et al. 2014. Eur J Obstet Gynecol Reprod Biol. 180: 172-9. PMID: 25043745
4. Analysis of CD15, CD57 and HIF-1α in biopsies of patients with peri-implantitis.  |  de Araújo, MF., et al. 2017. Pathol Res Pract. 213: 1097-1101. PMID: 28778496
5. Endoplasmic reticulum stress induced LOX-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma.  |  Nan, J., et al. 2018. Immunology. 154: 144-155. PMID: 29211299
6. Clinically relevant umbilical cord inflammation identified based on CD15-associated vasculitis patterning.  |  Hatano, Y., et al. 2021. Placenta. 108: 39-46. PMID: 33813362
7. G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment.  |  Maneta, E., et al. 2022. Clin Transl Immunology. 11: e1395. PMID: 35602884
8. Histopathologic Findings in Large for Gestational Age Placentas and Correlation With CD15 Immunohistochemistry.  |  Mehreen, A., et al. 2023. Pediatr Dev Pathol. 26: 458-465. PMID: 37599445
9. CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal Cell Carcinoma.  |  Stenzel, PJ., et al. 2024. Pathobiology. 91: 219-229. PMID: 37963432
10. The ratio of intratumoral CD15+ neutrophils to CD8+ lymphocytes predicts recurrence in patients with gastric cancer after curative resection.  |  Watanabe, J., et al. 2024. Cancer Rep (Hoboken). 7: e2099. PMID: 38837676

The preferred CD15 antibody is CD15 Antibody (C3D-1): sc-19648.