CD137L Antibody (AT113-2): sc-58949

CD137L Antibody (AT113-2) is a rat monoclonal IgG1 antibody that detects CD137L in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD137L, also known as 4-1BB ligand, plays a crucial role in the immune response by providing a costimulatory signal to T cells, which is essential for their activation and proliferation. CD137L is primarily located on antigen-presenting cells, including B cells, macrophages, and dendritic cells, where CD137L interacts with CD137 on activated T cells. CD137L binding to CD137 not only enhances T cell activation but also promotes the generation of cytotoxic T lymphocytes, which are vital for targeting and eliminating infected or cancerous cells. Additionally, CD137L and CD137 interaction can influence the survival and function of peripheral monocytes, highlighting the importance of this pathway in maintaining immune homeostasis. The presence of soluble forms of CD137L in the serum of patients with autoimmune conditions, such as rheumatoid arthritis, suggests a potential regulatory role in modulating immune responses, making CD137L a significant target for therapeutic interventions in immune-related diseases.

The preferred CD137L antibody is CD137L Antibody (G-10): sc-398933.