CCNJL Antibody (B-1): sc-376075
- CCNJL Antibody (B-1) is a mouse monoclonal IgG1 κ CCNJL antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 19-47 near the N-terminus of CCNJL of human origin
- CCNJL Antibody (B-1) is recommended for detection of CCNJL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CCNJL Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CCNJL Antibody (B-1). This work is in progress.
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CCNJL Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCNJL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-CCNJL antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCNJL, also known as Cyclin J, plays a crucial role in regulating the cell cycle by forming complexes with cyclin-dependent kinases (Cdks), which are essential for activating protein kinase functions necessary for cell division. CCNJL (B-1) monoclonal antibody is particularly important for studying early embryonic development, where kinase activity is required for rapid division cycles. CCNJL consists of 435 amino acids and features a cyclin N-terminal domain, with two isoforms generated through alternative splicing, allowing for functional diversity in cellular processes. Cyclin concentrations fluctuate throughout the cell cycle to ensure appropriate responses to developmental cues, making CCNJL and its interactions vital for understanding cell cycle regulation and potential implications in developmental biology and cancer research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCNJL Antibody (B-1) References:
- Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. | Kong, M., et al. 2000. EMBO J. 19: 1378-88. PMID: 10716937
- A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. | Kolonin, MG. and Finley, RL. 2000. Dev Biol. 227: 661-72. PMID: 11071782
- Complete sequencing and characterization of 21,243 full-length human cDNAs. | Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
- A roller coaster ride with the mitotic cyclins. | Fung, TK. and Poon, RY. 2005. Semin Cell Dev Biol. 16: 335-42. PMID: 15840442
- New insights for understanding the transcription-coupled repair pathway. | Sarasin, A. and Stary, A. 2007. DNA Repair (Amst). 6: 265-9. PMID: 17194629
- Molecular mechanisms of skin aging: state of the art. | Makrantonaki, E. and Zouboulis, CC. 2007. Ann N Y Acad Sci. 1119: 40-50. PMID: 18056953
- Human cyclin F. | Bai, C., et al. 1994. EMBO J. 13: 6087-98. PMID: 7813445
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCNJL Antibody (B-1) | sc-376075 | 200 µg/ml | $322.00 | |||
CCNJL Antibody (B-1) AC | sc-376075 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CCNJL Antibody (B-1) HRP | sc-376075 HRP | 200 µg/ml | $322.00 | |||
CCNJL Antibody (B-1) FITC | sc-376075 FITC | 200 µg/ml | $336.00 | |||
CCNJL Antibody (B-1) PE | sc-376075 PE | 200 µg/ml | $349.00 | |||
CCNJL Antibody (B-1) Alexa Fluor® 488 | sc-376075 AF488 | 200 µg/ml | $364.00 | |||
CCNJL Antibody (B-1) Alexa Fluor® 546 | sc-376075 AF546 | 200 µg/ml | $364.00 | |||
CCNJL Antibody (B-1) Alexa Fluor® 594 | sc-376075 AF594 | 200 µg/ml | $364.00 | |||
CCNJL Antibody (B-1) Alexa Fluor® 647 | sc-376075 AF647 | 200 µg/ml | $364.00 | |||
CCNJL Antibody (B-1) Alexa Fluor® 680 | sc-376075 AF680 | 200 µg/ml | $364.00 | |||
CCNJL Antibody (B-1) Alexa Fluor® 790 | sc-376075 AF790 | 200 µg/ml | $364.00 | |||
CCNJL (B-1) Neutralizing Peptide | sc-376075 P | 100 µg/0.5 ml | $69.00 |