CCL14 Antibody (E-12): sc-376152
- CCL14 Antibody (E-12) is a mouse monoclonal IgG1 κ CCL14 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 65-93 at the C-terminus of CCL14 of human origin
- CCL14 Antibody (E-12) is recommended for detection of CCL14 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CCL14 Antibody (E-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CCL14 Antibody (E-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with CCL14 Antibody (E-12) (see ordering information below).
QUICK LINKS
CCL14 Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCL14 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CCL14 (E-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCL14, a member of the intercrine β (chemokine C-C) family, plays a crucial role in the immune response by acting as a chemotactic factor that attracts monocytes, eosinophils, and T cells to sites of inflammation. CCL14 is primarily secreted and functions by binding to specific receptors, including CCR1, CCR3, and CCR5, which are essential for mediating immune cell migration. Notably, the processed form of CCL14, known as HCC-1(9-74), exhibits enhanced receptor affinity and is vital for the recruitment of immune cells during inflammatory responses. CCL14 has been shown to promote the proliferation of CD34 myeloid progenitor cells, highlighting its importance in hematopoiesis and immune system regulation. Understanding CCL14 function and interactions is critical for developing therapeutic strategies targeting inflammatory diseases and immune disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCL14 Antibody (E-12) References:
- Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages. | Münch, J., et al. 2002. Antimicrob Agents Chemother. 46: 982-90. PMID: 11897579
- Chemokine-protease interactions in cancer. | Van Damme, J., et al. 2004. Semin Cancer Biol. 14: 201-8. PMID: 15246056
- n-Nonanoyl-CC chemokine ligand 14, a potent CC chemokine ligand 14 analogue that prevents the recruitment of eosinophils in allergic airway inflammation. | Forssmann, U., et al. 2004. J Immunol. 173: 3456-66. PMID: 15322211
- Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs. | Shen, Y., et al. 2004. BMC Immunol. 5: 20. PMID: 15369600
- Structural and functional characterization of CC chemokine CCL14. | Blain, KY., et al. 2007. Biochemistry. 46: 10008-15. PMID: 17691823
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCL14 Antibody (E-12) | sc-376152 | 200 µg/ml | $316.00 | |||
CCL14 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-526005 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCL14 Antibody (E-12) AC | sc-376152 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCL14 Antibody (E-12) HRP | sc-376152 HRP | 200 µg/ml | $316.00 | |||
CCL14 Antibody (E-12) FITC | sc-376152 FITC | 200 µg/ml | $330.00 | |||
CCL14 Antibody (E-12) PE | sc-376152 PE | 200 µg/ml | $343.00 | |||
CCL14 Antibody (E-12) Alexa Fluor® 488 | sc-376152 AF488 | 200 µg/ml | $357.00 | |||
CCL14 Antibody (E-12) Alexa Fluor® 546 | sc-376152 AF546 | 200 µg/ml | $357.00 | |||
CCL14 Antibody (E-12) Alexa Fluor® 594 | sc-376152 AF594 | 200 µg/ml | $357.00 | |||
CCL14 Antibody (E-12) Alexa Fluor® 647 | sc-376152 AF647 | 200 µg/ml | $357.00 | |||
CCL14 Antibody (E-12) Alexa Fluor® 680 | sc-376152 AF680 | 200 µg/ml | $357.00 | |||
CCL14 Antibody (E-12) Alexa Fluor® 790 | sc-376152 AF790 | 200 µg/ml | $357.00 | |||
CCL14 (E-12) Neutralizing Peptide | sc-376152 P | 100 µg/0.5 ml | $68.00 |