CBX7 Antibody (G-3): sc-376274

CBX7 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects CBX7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CBX7 (G-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CBX7, also known as Chromobox protein homolog 7, is a 251 amino acid nuclear protein characterized by one N-terminal chromo domain and one C-terminal Pc box. CBX7 is predominantly expressed in the kidney, brain, heart, and skeletal muscle, with lower levels found in peripheral blood leukocytes. CBX7 plays a crucial role as a component of the chromatin-associated polycomb complex, which is essential for maintaining the transcriptionally repressed state of target genes. CBX7 is involved in post-translational modifications that influence chromatin structure, thereby extending the cellular lifespan of epithelial cells by repressing p14 ARF expression and inhibiting telomerase activity. This regulatory function is significant as CBX7 contributes to the control of cell cycle progression and has implications in tumorigenesis, particularly in the development of follicular lymphoma and thyroid cancer.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CBX7 Antibody (G-3) References:

1. Polycomb CBX7 has a unifying role in cellular lifespan.  |  Gil, J., et al. 2004. Nat Cell Biol. 6: 67-72. PMID: 14647293
2. Role of polycomb group proteins in stem cell self-renewal and cancer.  |  Gil, J., et al. 2005. DNA Cell Biol. 24: 117-25. PMID: 15699631
3. Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3.  |  Suarez-Merino, B., et al. 2005. Neuro Oncol. 7: 20-31. PMID: 15701279
4. CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.  |  Bernard, D., et al. 2005. Oncogene. 24: 5543-51. PMID: 15897876
5. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.  |  Bernstein, E., et al. 2006. Mol Cell Biol. 26: 2560-9. PMID: 16537902
6. Role of the chromobox protein CBX7 in lymphomagenesis.  |  Scott, CL., et al. 2007. Proc Natl Acad Sci U S A. 104: 5389-94. PMID: 17374722
7. Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer.  |  Pallante, P., et al. 2008. Cancer Res. 68: 6770-8. PMID: 18701502
8. Polycomb protein family member CBX7 plays a critical role in cancer progression.  |  Pallante, P., et al. 2015. Am J Cancer Res. 5: 1594-601. PMID: 26175930
9. CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.  |  Huang, Z., et al. 2021. Cell Death Dis. 12: 537. PMID: 34035231
10. CBX7 is Dualistic in Cancer Progression Based on its Function and Molecular Interactions.  |  Li, J., et al. 2021. Front Genet. 12: 740794. PMID: 34659360
11. Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.  |  Cho, KW., et al. 2023. Circulation. 147: 1823-1842. PMID: 37158107
12. CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.  |  Dou, Z., et al. 2024. Sci Rep. 14: 11008. PMID: 38744845

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CBX7 Antibody (G-3) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-CBX7 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CBX7 Antibody (G-3) Specifications

Alternate Product Name: CBX7

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 74-158

Epitope Target: CBX7

Epitope Species: mouse

Product Reactivity/Detection: CBX7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for CBX7 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent