caveolin-3 Antibody (A-3): sc-5310

caveolin-3 Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects the caveolin-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). caveolin-3 monoclonal antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Caveolin-3 plays a crucial role in the formation of caveolae, which are specialized flask-shaped invaginations of the plasma membrane that are essential for various cellular processes, including endocytosis and signal transduction. These structures are particularly important in muscle cells, where caveolin-3 is predominantly expressed, as they facilitate the compartmentalization of signaling molecules and the regulation of lipid metabolism. The presence of caveolin-3 is vital for maintaining the integrity of caveolae and ensuring proper cellular communication, especially in response to mechanical stress and during muscle contraction. Additionally, caveolin-3 interacts with other caveolins and signaling proteins, contributing to the dynamic regulation of cellular signaling pathways. Understanding the function and importance of caveolin-3 can provide insights into various physiological processes and potential pathological conditions, making caveolin-3 monoclonal antibody (A-3) an invaluable tool for researchers studying muscle biology and related fields.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

caveolin-3 Antibody (A-3) References:

1. Caveolin, a protein component of caveolae membrane coats.  |  Rothberg, KG., et al. 1992. Cell. 68: 673-82. PMID: 1739974
2. Caveolin-3 and Caveolae regulate ventricular repolarization.  |  Markandeya, YS., et al. 2023. J Mol Cell Cardiol. 177: 38-49. PMID: 36842733
3. Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals.  |  Meng, Z., et al. 2023. Circulation. 147: 1162-1179. PMID: 36883479
4. Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts.  |  Sadoshima, J. 2023. Circulation. 147: 1180-1182. PMID: 37036910
5. Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations.  |  Benzoni, P., et al. 2024. Int J Mol Sci. 25: PMID: 38256054
6. Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form.  |  Fan, JY., et al. 1983. J Cell Sci. 61: 219-30. PMID: 6885939
7. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.  |  Lisanti, MP., et al. 1994. J Cell Biol. 126: 111-26. PMID: 7517942
8. VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.  |  Zurzolo, C., et al. 1994. EMBO J. 13: 42-53. PMID: 8306971
9. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.  |  Scherer, PE., et al. 1996. Proc Natl Acad Sci U S A. 93: 131-5. PMID: 8552590
10. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle.  |  Tang, Z., et al. 1996. J Biol Chem. 271: 2255-61. PMID: 8567687
11. Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.  |  Li, S., et al. 1996. J Biol Chem. 271: 3863-8. PMID: 8632005
12. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins.  |  Song, KS., et al. 1996. J Biol Chem. 271: 15160-5. PMID: 8663016

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caveolin-3 Antibody (A-3) has 65 citations in a variety of scientific publications.

Primary antibodies like Anti-caveolin-3 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caveolin-3 Antibody (A-3) Specifications

Alternate Product Name: caveolin-3

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 3-40

Epitope Target: caveolin-3

Epitope Species: mouse

Product Reactivity/Detection: caveolin-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 65 citations in various scientific publications

Available Conjugates/Forms for caveolin-3 Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred caveolin-3 antibody is caveolin-3 Antibody (C-2): sc-55518.