caveolin-1 Antibody (7C8): sc-53564

caveolin-1 Antibody (7C8) is a mouse monoclonal IgG2b kappa light chain antibody that targets caveolin-1, also known as CAV1, a principal component of caveolae, small invaginations in the plasma membrane of various cell types. Anti-caveolin-1 antibody (7C8) is raised against purified Glut4 vesicles from adipocytes of rat origin, enabling the detection of caveolin-1 in mouse, rat, human, and, to a lesser extent, hamster samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Caveolin-1 plays a crucial role in the formation and function of caveolae, which are involved in processes like endocytosis, signal transduction, and lipid regulation. Located primarily at the plasma membrane, caveolin-1 contributes to the structural integrity of caveolae and is involved in the compartmentalization of signaling molecules, including G protein-coupled receptors. Additionally, caveolin-1 is implicated in various cellular functions such as the transcytosis of macromolecules, uptake of small molecules via potocytosis, and regulation of cholesterol homeostasis. Caveolin-1 monoclonal antibody (7C8) is available in both non-conjugated form and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing flexibility for diverse experimental setups. Anti-caveolin-1 antibody (7C8) is recommended for researchers investigating the roles of caveolae in cellular physiology and pathology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

caveolin-1 Antibody (7C8) References:

1. [Letter: Lumbago--differential diagnosis and surgical treatment. Comments to A. Göb, S. Stotz, Münch. med. Wschr. 116 (1974) 273].  |  Scheef, SE. 1975. MMW Munch Med Wochenschr. 117: 1359-60. PMID: 126375
2. Caveolin, a protein component of caveolae membrane coats.  |  Rothberg, KG., et al. 1992. Cell. 68: 673-82. PMID: 1739974
3. Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form.  |  Fan, JY., et al. 1983. J Cell Sci. 61: 219-30. PMID: 6885939
4. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.  |  Lisanti, MP., et al. 1994. J Cell Biol. 126: 111-26. PMID: 7517942
5. VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.  |  Zurzolo, C., et al. 1994. EMBO J. 13: 42-53. PMID: 8306971
6. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.  |  Scherer, PE., et al. 1996. Proc Natl Acad Sci U S A. 93: 131-5. PMID: 8552590
7. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle.  |  Tang, Z., et al. 1996. J Biol Chem. 271: 2255-61. PMID: 8567687
8. Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.  |  Li, S., et al. 1996. J Biol Chem. 271: 3863-8. PMID: 8632005
9. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins.  |  Song, KS., et al. 1996. J Biol Chem. 271: 15160-5. PMID: 8663016

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-caveolin-1 Antibody (7C8) has 109 citations in a variety of scientific publications.

Primary antibodies like Anti-caveolin-1 Antibody (7C8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

caveolin-1 Antibody (7C8) Specifications

Alternate Product Name: caveolin-1

Product Clone Name: 7C8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: caveolin-1

Epitope Species: rat

Product Reactivity/Detection: caveolin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 109 citations in various scientific publications

Available Conjugates/Forms for caveolin-1 Antibody (7C8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p-caveolin-1 antibody is p-caveolin-1 Antibody (G-10): sc-373836.