cathepsin L Antibody (E-5): sc-390385

Cathepsin L Antibody (E-5) is a mouse monoclonal IgG3 kappa light chain antibody engineered to recognize an epitope mapping between amino acids 263-291 at the C-terminus of cathepsin L, also known as CTSL, major excreted protein (MEP), or CATL. Anti-cathepsin L antibody (E-5) exhibits robust reactivity with cathepsin L from mouse, rat, and human origins, making it ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cathepsin L is a lysosomal cysteine protease that plays a critical role in the intracellular degradation of proteins, including collagen, elastin, and α-1 protease inhibitor, which is essential for maintaining cellular metabolism and homeostasis. Structurally, cathepsin L functions as a dimer composed of disulfide-linked heavy and light chains derived from a single precursor protein, a configuration that is vital for enzymatic activity and stability. Cathepsin L interacts with several key proteins, such as cystatins which act as natural inhibitors regulating proteolytic activity, and is involved in pathways related to extracellular matrix remodeling by interacting with matrix metalloproteinases (MMPs). These interactions are crucial for processes like tissue repair, immune responses, and tumor progression, highlighting the importance of accurately detecting and studying cathepsin L in various biological contexts. Cathepsin L (E-5) monoclonal antibody allows researchers to precisely analyze the expression, processing, and functional dynamics of cathepsin L, facilitating advancements in understanding its role in diseases such as cancer, arthritis, and cardiovascular disorders.

The preferred cathepsin L antibody is cathepsin L Antibody (33/2): sc-32320.