CAT-4 Antibody (B-2): sc-376557

CAT-4 Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CAT-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CAT-4 Antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. As a member of the amino acid transporter family, CAT-4 (cationic amino acid transporter 4), also known as Solute Carrier Family 7 Member 4, is a 635 amino acid multi-pass membrane protein that plays a crucial role in the transport of cationic amino acids such as arginine, lysine, and ornithine. This transport mechanism, referred to as "system y+", is characterized by pH insensitivity, stereoselectivity, and independence from sodium ions, while being inhibited by neutral amino acids in the presence of sodium. CAT-4 expression is notably high in the testis, placenta, and brain, highlighting its importance in various physiological processes. Multiple transmembrane domains in CAT-4′s structure facilitate selective transport of critical amino acids across cellular membranes. Disruptions in the gene encoding CAT-4, located on a specific chromosomal band, have been linked to velocardiofacial syndrome (also known as DiGeorge syndrome), a condition marked by cardiac defects and distinctive facial features. This connection underscores CAT-4′s significance in both normal physiology and disease states, making anti-CAT-4 antibody (B-2) a valuable tool for researchers studying its role in health and disease.

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CAT-4 Antibody (B-2) References:

1. Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.  |  Hammermann, R., et al. 2001. Amino Acids. 21: 211-9. PMID: 11665818
2. Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity.  |  Wolf, S., et al. 2002. Biochem J. 364: 767-75. PMID: 12049641
3. The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors.  |  Rotoli, BM., et al. 2005. FASEB J. 19: 810-2. PMID: 15746185
4. Structure and function of cationic amino acid transporters (CATs).  |  Closs, EI., et al. 2006. J Membr Biol. 213: 67-77. PMID: 17417706
5. Molecular mechanisms and diagnosis of chromosome 22q11.2 rearrangements.  |  Emanuel, BS. 2008. Dev Disabil Res Rev. 14: 11-8. PMID: 18636632
6. CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines.  |  Abdelmagid, SA., et al. 2011. J Cell Biochem. 112: 1084-92. PMID: 21308737
7. L-arginine stimulates CAT-1-mediated arginine uptake and regulation of inducible nitric oxide synthase for the growth of chick intestinal epithelial cells.  |  Yuan, C., et al. 2015. Mol Cell Biochem. 399: 229-36. PMID: 25336270
8. A comparison of the assessment of health status between CCQ and CAT in a Chinese COPD clinical population: a cross-sectional analysis.  |  Zhou, Z., et al. 2018. Int J Chron Obstruct Pulmon Dis. 13: 1675-1682. PMID: 29872285
9. Binuclear Triphenylantimony(V) Catecholates through N-Donor Linkers: Structural Features and Redox Properties.  |  Poddel'sky, AI., et al. 2022. Molecules. 27: PMID: 36235022
10. Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis.  |  Lan, TY., et al. 2022. Front Nutr. 9: 1064507. PMID: 36687723
11. Computerized-adaptive testing versus short forms for pediatric inflammatory bowel disease patient-reported outcome assessment.  |  Brenner, EJ., et al. 2023. J Clin Transl Sci. 7: e109. PMID: 37250995
12. The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome.  |  Sperandeo, MP., et al. 1998. Genomics. 49: 230-6. PMID: 9598310

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CAT-4 Antibody (B-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CAT-4 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CAT-4 Antibody (B-2) Specifications

Alternate Product Name: CAT-4

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 291-323

Epitope Target: CAT-4

Epitope Species: human

Product Reactivity/Detection: CAT-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CAT-4 Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin