CaSR Antibody (6D4): sc-47741
- CaSR Antibody (6D4) is a mouse monoclonal IgG1 κ CaSR antibody, cited in 21 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to amino acids 15-29 in the extracelllular N-terminus of rat CaSR
- CaSR Antibody (6D4) is recommended for detection of CaSR of mouse, rat, human and rabbit origin by WB, IP and IF
- Anti-CaSR Antibody (6D4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CaSR (6D4): sc-47741.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CaSR Antibody (6D4). This work is in progress.
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SEE ALSO...
CaSR Antibody (6D4) is a mouse monoclonal IgG1 kappa light chain antibody that detects CaSR protein of mouse, rat, human, and rabbit origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CaSR Antibody (6D4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The extracellular calcium-sensing receptor (CaSR), also known as the parathyroid cell calcium-sensing receptor, is an integral membrane protein that plays a crucial role in calcium homeostasis by detecting and responding to changes in extracellular calcium levels. CaSR is primarily located in the parathyroid glands and kidneys, where CaSR functions as a sensor to regulate calcium concentration in the bloodstream. CaSR′s location is crucial for modulating parathyroid hormone secretion and renal calcium reabsorption, thereby maintaining calcium balance in the body. Mutations in CaSR can lead to significant disorders, such as autosomal dominant hypocalcemia and familial hypocalciuric hypercalcemia, highlighting CaSR′s critical role in calcium metabolism. CaSR is also expressed in other tissues, including the intestine, placenta, and brain, indicating CaSR′s diverse physiological functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CaSR Antibody (6D4) References:
- Autosomal dominant hypoparathyroidism associated with short stature and premature osteoarthritis. | Stock, JL., et al. 1999. J Clin Endocrinol Metab. 84: 3036-40. PMID: 10487661
- A novel mutation in Ca2+-sensing receptor gene in familial hypocalciuric hypercalcemia. | Nakayama, T., et al. 2001. Endocrine. 15: 277-82. PMID: 11762699
- A novel mutation (E767K) in the second extracellular loop of the calcium sensing receptor in a family with autosomal dominant hypocalcemia. | Uçkun-Kitapçi, A., et al. 2005. Am J Med Genet A. 132A: 125-9. PMID: 15551332
- Molecular cloning of a putative Ca(2+)-sensing receptor cDNA from human kidney. | Aida, K., et al. 1995. Biochem Biophys Res Commun. 214: 524-9. PMID: 7677761
- Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. | Garrett, JE., et al. 1995. J Biol Chem. 270: 12919-25. PMID: 7759551
- Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. | Bikle, DD., et al. 1996. J Clin Invest. 97: 1085-93. PMID: 8613532
- Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion. | Freichel, M., et al. 1996. Endocrinology. 137: 3842-8. PMID: 8756555
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CaSR Antibody (6D4) | sc-47741 | 200 µg/ml | $316.00 | |||
CaSR Antibody (6D4) AC | sc-47741 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CaSR Antibody (6D4) HRP | sc-47741 HRP | 200 µg/ml | $316.00 | |||
CaSR Antibody (6D4) FITC | sc-47741 FITC | 200 µg/ml | $330.00 | |||
CaSR Antibody (6D4) PE | sc-47741 PE | 200 µg/ml | $343.00 | |||
CaSR Antibody (6D4) Alexa Fluor® 488 | sc-47741 AF488 | 200 µg/ml | $357.00 | |||
CaSR Antibody (6D4) Alexa Fluor® 546 | sc-47741 AF546 | 200 µg/ml | $357.00 | |||
CaSR Antibody (6D4) Alexa Fluor® 594 | sc-47741 AF594 | 200 µg/ml | $357.00 | |||
CaSR Antibody (6D4) Alexa Fluor® 647 | sc-47741 AF647 | 200 µg/ml | $357.00 | |||
CaSR Antibody (6D4) Alexa Fluor® 680 | sc-47741 AF680 | 200 µg/ml | $357.00 | |||
CaSR Antibody (6D4) Alexa Fluor® 790 | sc-47741 AF790 | 200 µg/ml | $357.00 |