Date published: 2025-12-31

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Caspase-9 Inhibitor III (CAS 403848-57-7)

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Alternate Names:
Ac-LEHD-CMK
Application:
Caspase-9 Inhibitor III is a potent and irreversible caspase-9 inhibitor
CAS Number:
403848-57-7
Purity:
≥95%
Molecular Weight:
587.02
Molecular Formula:
C24H35ClN6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Caspase-9 Inhibitor III is a chemical compound used primarily in the field of apoptosis research. As an inhibitor of caspase-9, it allows scientists to probe the intrinsic pathway of programmed cell death by blocking the activity of this key initiator caspase. This inhibition is particularly valuable in studying the cascade of events leading to cell death, as well as the survival mechanisms that cells may invoke in response to apoptotic signals. Researchers utilize this inhibitor to dissect the role of caspase-9 in various cellular processes, including development, normal cellular turnover, and response to cellular stress. Additionally, it is used in molecular biology to manipulate apoptosis in cell culture, thereby aiding in the elucidation of complex cell signaling pathways and the determination of how these pathways are altered in various cellular states. Caspase-9 Inhibitor III is also a tool for investigating the interplay between apoptosis and other cellular processes like autophagy, providing broader insights into cellular homeostasis.


Caspase-9 Inhibitor III (CAS 403848-57-7) References

  1. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury.  |  Mocanu, MM., et al. 2000. Br J Pharmacol. 130: 197-200. PMID: 10807653
  2. Galectin-1 induced activation of the mitochondrial apoptotic pathway: evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes.  |  Lange, F., et al. 2009. Histochem Cell Biol. 132: 211-23. PMID: 19381674
  3. The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis.  |  Kina, K., et al. 2011. J Immunol. 186: 5323-32. PMID: 21451106
  4. The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells.  |  Alaimo, A., et al. 2011. Neurochem Int. 59: 297-308. PMID: 21704098
  5. Different signaling pathways stimulate a disintegrin and metalloprotease-17 (ADAM17) in neutrophils during apoptosis and activation.  |  Wang, Y., et al. 2011. J Biol Chem. 286: 38980-8. PMID: 21949123
  6. Activation-induced cell death of memory CD8+ T cells from pleural effusion of lung cancer patients is mediated by the type II Fas-induced apoptotic pathway.  |  Prado-Garcia, H., et al. 2012. Cancer Immunol Immunother. 61: 1065-80. PMID: 22159518
  7. C/EBP-α ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo.  |  Tao, LL., et al. 2012. Apoptosis. 17: 492-502. PMID: 22307857
  8. Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition.  |  Li, H., et al. 2012. Exp Hematol. 40: 548-563.e2. PMID: 22366408
  9. Organization and functions of glycolipid-enriched microdomains in phagocytes.  |  Ekyalongo, RC., et al. 2015. Biochim Biophys Acta. 1851: 90-7. PMID: 24968752
  10. Differential impact of bortezomib on HL-60 and K562 cells.  |  Kliková, K., et al. 2015. Gen Physiol Biophys. 34: 33-42. PMID: 25367763
  11. The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization.  |  Khatri, N., et al. 2018. J Neurosci. 38: 363-378. PMID: 29175955
  12. Regulated Necrosis Orchestrates Microglial Cell Death in Manganese-Induced Toxicity.  |  Porte Alcon, S., et al. 2018. Neuroscience. 393: 206-225. PMID: 30316909
  13. STAT3 activates the anti-apoptotic form of caspase 9 in oncovirus-infected B lymphocytes.  |  Koganti, S., et al. 2020. Virology. 540: 160-164. PMID: 31928997

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Caspase-9 Inhibitor III, 1 mg

sc-300327
1 mg
$152.00

Caspase-9 Inhibitor III, 5 mg

sc-300327A
5 mg
$474.00