Caspase-9 Inhibitor III CAS: 403848-57-7
MF: C24H35ClN6O9
MW: 587.02
A potent and irreversible caspase-9 inhibitor.

Caspase-9 Inhibitor III (CAS 403848-57-7)

Caspase-9 Inhibitor III | CAS 403848-57-7 is rated 5.0 out of 5 by 1.
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Alternate Names: Ac-LEHD-CMK
Application: Caspase-9 Inhibitor III is a potent and irreversible caspase-9 inhibitor
CAS Number: 403848-57-7
Purity: ≥95%
Molecular Weight: 587.02
Molecular Formula: C24H35ClN6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-6 Kit (sc-4266 AK).


References

1. Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130: 197-200. PMID: 10807653

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), and sparingly soluble in water (1 mg/ml).
Storage :
Store at -20° C
Boiling Point :
1113.45° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760347
MDL Number :
MFCD02259690
SMILES :
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Caspase-9 Inhibitor III (CAS 403848-57-7)  Product Citations

See how others have used Caspase-9 Inhibitor III (CAS 403848-57-7). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25367763  Kliková, K. et al. 2015. General physiology and biophysics. 34: 33-42.

PMID: # 31928997  Virology. 540: 160-164.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Use routinely in our lab and works fine Use routinely in our lab and works fine.
Date published: 2015-07-17
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