caspase-2 inhibitor
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Caspase-2 inhibitor (Z-VDVAD-FMK) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. In a study of 7-ketocholesterol (sc-210630)-induced cell death and the association with polar lipid accumulation, the effects of Z-VDVAD-FMK on the lipid profile was evaluated by staining with Nile Red (sc-203747). Caspase-2 inhibitor has also been shown to inhibit programmed macrophage cell death induced by Brucella species gram-negative bacteria.
Purity: Single spot by TLC.
caspase-2 inhibitor References
- Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. | Gamen, S., et al. 2000. Exp Cell Res. 258: 223-35. PMID: 10912804
- Caspases-2, -3, and -7 are involved in thapsigargin-induced apoptosis of SH-SY5Y neuroblastoma cells. | Dahmer, MK. 2005. J Neurosci Res. 80: 576-83. PMID: 15825194
- Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neurons. | Almeida, S., et al. 2006. J Cell Biochem. 98: 93-101. PMID: 16365893
- PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. | Yeung, BH., et al. 2006. J Biol Chem. 281: 11923-32. PMID: 16446371
- H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells. | Jangi, SM., et al. 2006. Carcinogenesis. 27: 1787-96. PMID: 16569656
- Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy. | Vejux, A., et al. 2007. Cytometry A. 71: 550-62. PMID: 17458884
- Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus. | Chen, F. and He, Y. 2009. PLoS One. 4: e6830. PMID: 19714247
- Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. | Kim, BM. and Hong, SH. 2011. Apoptosis. 16: 184-97. PMID: 21107704
- Endoplasmic reticulum stress associated with caspases-4 and -2 mediates korbazol-induced B-chronic lymphocytic leukemia cell apoptosis. | Popovic, S., et al. 2010. J BUON. 15: 783-90. PMID: 21229646
- miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke. | Zhang, R., et al. 2019. Brain Res. 1714: 18-26. PMID: 30779911
- Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia. | Hååg, P., et al. 2022. Cell Death Discov. 8: 284. PMID: 35690610
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-2 inhibitor, 1 mg | sc-3072 | 1 mg | $285.00 |