CASK Antibody (7): sc-135857
- CASK Antibody (7) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 353-486 of CASK of rat origin
- recommended for detection of CASK of mouse, rat, human and canine origin by WB, IP and IF; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CASK Antibody (7). This work is in progress.
QUICK LINKS
SEE ALSO...
CASK Antibody (7) is a mouse monoclonal IgG1 antibody that detects CASK in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-CASK antibody (7) recognizes CASK, a member of the MAGUK (membrane-associated guanylate kinase homologs) family, which plays a pivotal role in cell junction organization, tumor suppression, and intracellular signaling. CASK (7) antibody targets CASK primarily at neuronal synapses, where CASK interacts with cell-surface proteins like neurexin and syndecan, facilitating essential signaling processes. This localization is crucial for proper neuronal communication and synaptic function, as CASK is involved in the translocation to the nucleus, where CASK forms a complex with Tbr-1 that binds to specific DNA sequences, thereby regulating the expression of genes vital for cerebrocortical development, including Reelin. CASK′s ability to modulate gene expression underscores its importance in neurodevelopmental processes and highlights its potential as a target for studying neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CASK Antibody (7) References:
- The role of the MAGUK protein CASK in neural development and synaptic function. | Hsueh, YP. 2006. Curr Med Chem. 13: 1915-27. PMID: 16842202
- Structural constraints and functional divergences in CASK evolution. | LaConte, L. and Mukherjee, K. 2013. Biochem Soc Trans. 41: 1017-22. PMID: 23863172
- CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning. | Gillespie, JM. and Hodge, JJ. 2013. Front Mol Neurosci. 6: 27. PMID: 24062638
- Presynaptic dysfunction in CASK-related neurodevelopmental disorders. | Becker, M., et al. 2020. Transl Psychiatry. 10: 312. PMID: 32929080
- CASK regulates Notch pathway and functions as a tumor promoter in pancreatic cancer. | Qu, J., et al. 2021. Arch Biochem Biophys. 701: 108789. PMID: 33548214
- Functional analysis of CASK transcript variants expressed in human brain. | Tibbe, D., et al. 2021. PLoS One. 16: e0253223. PMID: 34133460
- Specific Deletion of CASK in Pancreatic β Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia Running Title: β Cell CASK Deletion Reduces Hyperinsulinemia. | Liu, X., et al. 2021. Diabetes.. PMID: 34675005
- Specific Deletion of CASK in Pancreatic β Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia Running Title: β Cell CASK Deletion Reduces Hyperinsulinemia. | Liu, X., et al. 2021. Diabetes.. PMID: 34957476
- CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. | McSweeney, D., et al. 2022. iScience. 25: 105187. PMID: 36262316
- Genetic evidence for splicing-dependent structural and functional plasticity in CASK protein. | Patel, PA., et al. 2024. J Med Genet. 61: 759-768. PMID: 38670634
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CASK Antibody (7) | sc-135857 | 50 µg/0.5 ml | $322.00 |