casein kinase IIβ Antibody (51): sc-135856

casein kinase IIβ Antibody (51) is a mouse monoclonal IgG1 antibody that detects casein kinase IIβ in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Casein kinase IIβ plays a crucial role in cellular signaling and regulation, functioning as a serine/threonine protein kinase that is integral to various cellular processes, including cell proliferation, differentiation, and survival. Casein kinase IIβ is primarily located in the cytoplasm and nucleus, where casein kinase IIβ is involved in the phosphorylation of over 100 substrates, including key nuclear oncoproteins and transcription factors that regulate gene expression. The ability of casein kinase IIβ to modulate these critical pathways underscores its importance in maintaining cellular homeostasis and potential implications in cancer biology, as dysregulation of casein kinase IIβ activity can lead to uncontrolled cell growth. Anti-casein kinase IIβ antibody (51) is an essential tool for researchers aiming to explore the intricate roles of casein kinase IIβ in various biological contexts, providing insights into its function and interactions within the cell.

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casein kinase IIβ Antibody (51) References:

1. Phosphorylation of type II (beta) protein kinase C by casein kinase II.  |  Tominaga, M., et al. 1991. J Biochem. 110: 655-60. PMID: 1778990
2. Structure of the gene encoding human casein kinase II subunit beta.  |  Voss, H., et al. 1991. J Biol Chem. 266: 13706-11. PMID: 1856204
3. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes.  |  Yang, CP., et al. 2018. Nat Commun. 9: 838. PMID: 29483533
4. Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures.  |  Nakashima, M., et al. 2019. J Hum Genet. 64: 313-322. PMID: 30655572
5. Huaier Suppresses Breast Cancer Progression via linc00339/miR-4656/CSNK2B Signaling Pathway.  |  Wang, W., et al. 2019. Front Oncol. 9: 1195. PMID: 31781497
6. Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression.  |  Yu, S., et al. 2021. J Exp Clin Cancer Res. 40: 54. PMID: 33526068
7. De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway.  |  Asif, M., et al. 2022. HGG Adv. 3: 100111. PMID: 35571680
8. Splicing Interruption by Intron Variants in CSNK2B Causes Poirier-Bienvenu Neurodevelopmental Syndrome: A Focus on Genotype-Phenotype Correlations.  |  Zhang, W., et al. 2022. Front Neurosci. 16: 892768. PMID: 35774559
9. Predictive functional, statistical and structural analysis of CSNK2A1 and CSNK2B variants linked to neurodevelopmental diseases.  |  Unni, P., et al. 2022. Front Mol Biosci. 9: 851547. PMID: 36310603
10. Cell biological studies with monoclonal and polyclonal antibodies against human casein kinase II subunit beta demonstrate participation of the kinase in mitogenic signaling.  |  Lorenz, P., et al. 1993. J Biol Chem. 268: 2733-9. PMID: 8428947

The preferred casein kinase IIβ antibody is casein kinase IIβ Antibody (6D5): sc-12739.