casein kinase IIα Antibody (E-2): sc-365787

casein kinase IIα Antibody (E-2) is a mouse monoclonal IgG1 kappa kappa light chain antibody engineered to detect casein kinase IIα (CK2α), also known as CSNK2A1, across a broad range of species including mouse, rat, human, avian, canine, bovine, and porcine. Anti-CK2α antibody (E-2) targets a precise epitope mapping between amino acids 347-370 at the C-terminus of human CK2α, ensuring robust and reliable performance in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CK2α is a pivotal serine/threonine protein kinase involved in regulating numerous cellular processes, including cell cycle progression, DNA replication and repair, apoptosis, and transcriptional regulation. Structurally, CK2α forms a tetrameric complex with regulatory β subunits, which is essential for catalytic activity and substrate specificity. CK2α interacts with a variety of key proteins such as p53, NF-κB, PTEN, and various transcription factors, facilitating critical signaling pathways that maintain cellular homeostasis and influence gene expression. The extensive network of CK2α interactions underscores its significant role in processes like tumorigenesis, where dysregulation is frequently associated with cancer progression and resistance to apoptosis. With the ability to phosphorylate over a hundred substrates, CK2α is a crucial player in cellular function and represents a promising therapeutic target. CK2α monoclonal antibody (E-2) provides researchers with a dependable tool to explore the intricate interactions and functions of CK2α, thereby advancing the understanding of its role in both normal physiology and various disease states and supporting the development of targeted therapies in biomedical research.

The preferred casein kinase IIα antibody is casein kinase IIα Antibody (1AD9): sc-12738.