casein kinase Iε Antibody (D-7): sc-365259

Casein kinase Iε Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects casein kinase Iε in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Casein kinase Iε plays a crucial role in various cellular processes, particularly in the regulation of circadian rhythms and cell cycle progression, making casein kinase Iε essential for maintaining cellular homeostasis and responding to environmental cues. Casein kinase Iε (D-7) antibody targets proteins primarily located in the cytoplasm and nucleus, where casein kinase Iε participates in signaling pathways that influence gene expression and cellular proliferation. The localization of casein kinase Iε is significant because this positioning allows for precise regulation of activity in response to cellular signals, ensuring that phosphorylation events occur at the right time and place within the cell. Additionally, casein kinase Iε interacts with several key proteins, including the tumor suppressor p53 and various transcription factors, further underscoring casein kinase Iε′s importance in cellular signaling networks. With an ability to phosphorylate a diverse array of substrates, casein kinase Iε is integral to numerous biological processes, making anti-casein kinase Iε antibody (D-7) a valuable tool for researchers studying these critical pathways.

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casein kinase Iε Antibody (D-7) References:

1. Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.  |  Gietzen, KF. and Virshup, DM. 1999. J Biol Chem. 274: 32063-70. PMID: 10542239
2. cDNA cloning and chromosome mapping of the mouse casein kinase I epsilon gene (Csnk1e).  |  Kusuda, J., et al. 1999. Cytogenet Cell Genet. 87: 99-101. PMID: 10640823
3. Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon.  |  Keesler, GA., et al. 2000. Neuroreport. 11: 951-5. PMID: 10790862
4. Phosphorylation and regulation of beta-catenin by casein kinase I epsilon.  |  Sakanaka, C. 2002. J Biochem. 132: 697-703. PMID: 12417018
5. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.  |  Hino, S., et al. 2003. J Biol Chem. 278: 14066-73. PMID: 12556519
6. Regulation of casein kinase I epsilon activity by Wnt signaling.  |  Swiatek, W., et al. 2004. J Biol Chem. 279: 13011-7. PMID: 14722104
7. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.  |  Swiatek, W., et al. 2006. J Biol Chem. 281: 12233-41. PMID: 16513652
8. Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin.  |  McKenzie, JA., et al. 2006. FEBS Lett. 580: 2388-94. PMID: 16616143
9. Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.  |  Rodriguez, N., et al. 2012. EMBO Mol Med. 4: 952-63. PMID: 22707389
10. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.  |  Rivers, A., et al. 1998. J Biol Chem. 273: 15980-4. PMID: 9632646

The preferred casein kinase Iδ antibody is casein kinase Iδ Antibody (C-8): sc-55553.