casein kinase Iα Antibody (D-9): sc-74583

casein kinase Iα Antibody (D-9) is a mouse monoclonal IgG2b antibody that detects casein kinase Iα in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Casein kinase Iα, also known as CSNK1A1L, is a crucial serine/threonine protein kinase composed of 337 amino acids, playing a significant role in various cellular processes, including DNA replication, membrane trafficking, and the regulation of circadian rhythms. CSNK1A1L is primarily located in the cytoplasm, where CSNK1A1L is involved in the Wnt signaling pathway, a critical pathway for cell communication that influences cell fate and development. Proper functioning of casein kinase Iα is vital for maintaining cellular homeostasis and ensuring accurate cell cycle progression, as dysregulation can lead to various diseases, including cancer. By utilizing ATP within its protein kinase domain, casein kinase Iα phosphorylates a wide array of target proteins, thereby modulating their activity and contributing to the intricate signaling networks that govern cellular responses. Anti-casein kinase Iα antibody (D-9) is an essential tool for researchers investigating the roles of casein kinase Iα in health and disease, providing reliable detection and characterization in various experimental settings.

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casein kinase Iα Antibody (D-9) References:

1. The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism.  |  Gross, SD., et al. 1999. J Cell Sci. 112 (Pt 16): 2647-56. PMID: 10413673
2. The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.  |  Faundez, VV. and Kelly, RB. 2000. Mol Biol Cell. 11: 2591-604. PMID: 10930456
3. Identification of casein kinase Ialpha interacting protein partners.  |  Dubois, T., et al. 2002. FEBS Lett. 517: 167-71. PMID: 12062430
4. Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.  |  Quintavalle, M., et al. 2007. J Biol Chem. 282: 5536-44. PMID: 17166835
5. The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent.  |  Clokie, S., et al. 2009. FEBS J. 276: 6971-84. PMID: 19860830
6. A novel mechanism of keratin cytoskeleton organization through casein kinase Iα and FAM83H in colorectal cancer.  |  Kuga, T., et al. 2013. J Cell Sci. 126: 4721-31. PMID: 23902688
7. Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.  |  Masaki, T., et al. 2014. J Virol. 88: 7541-55. PMID: 24760886
8. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ.  |  Lee, JW., et al. 2019. J Med Chem. 62: 1989-1998. PMID: 30707835
9. A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins.  |  Gross, SD., et al. 1995. J Cell Biol. 130: 711-24. PMID: 7622570
10. Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties.  |  Zhang, J., et al. 1996. Biochemistry. 35: 16319-27. PMID: 8973207

The preferred casein kinase Iα antibody is casein kinase Iα Antibody (H-7): sc-74582.