Cardiotin Antibody (R2G): sc-53001

Cardiotin Antibody (R2G) is a mouse monoclonal IgM kappa light chain antibody that detects Cardiotin protein of mouse, rat, human, porcine, Xenopus, avian, feline, and canine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Cardiotin antibody (R2G) is available as the non-conjugated form. Cardiotin protein is a high molecular weight complex located in the mitochondrial membrane, playing a crucial role in maintaining the structural integrity and function of cardiac muscle cells. Cardiotin′s structure consists of two subunits that share a highly conserved N-terminal 14 amino acid sequence, showing significant homology to human skeletal muscle α-actinin. This structural similarity suggests that Cardiotin forms a tetrameric transmembrane complex, with N-terminus positioned on the cytoplasmic side of the membrane, allowing effective interaction with actin filaments. Such interactions are vital for proper cardiac contractility and cellular signaling. During instances of cardiac contractile dysfunction, Cardiotin distribution is altered in pathological cardiomyocytes, such as those found in chronic ischemic myocardium. Cardiotin monoclonal antibody (R2G) can be utilized in immunohistochemistry with paraffin-embedded sections (IHCP) to detect disturbances in mitochondrial activity within cardiomyocytes, particularly in conditions like chronic ischemia or chronic atrial fibrillation, making this tool essential for researchers studying cardiac health and disease.

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Cardiotin Antibody (R2G) References:

1. Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts.  |  Dispersyn, GD., et al. 2001. Cardiovasc Res. 51: 230-40. PMID: 11470462
2. Time course of atrial fibrillation-induced cellular structural remodeling in atria of the goat.  |  Ausma, J., et al. 2001. J Mol Cell Cardiol. 33: 2083-94. PMID: 11735256
3. Dissociation of cardiomyocyte apoptosis and dedifferentiation in infarct border zones.  |  Dispersyn, GD., et al. 2002. Eur Heart J. 23: 849-57. PMID: 12042006
4. Piperidine: effects on locomotor activity and brain monoamine turnover.  |  Alm, B. 1976. Psychopharmacology (Berl). 50: 301-4. PMID: 826977
5. Biochemical characterization of cardiotin, a sarcoplasmic reticulum associated protein.  |  Schaart, G., et al. 1997. FEBS Lett. 403: 168-72. PMID: 9042960
6. Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation.  |  Ausma, J., et al. 1997. Am J Pathol. 151: 985-97. PMID: 9327732

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cardiotin Antibody (R2G) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cardiotin Antibody (R2G) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cardiotin Antibody (R2G) Specifications

Alternate Product Name: Cardiotin complex

Product Clone Name: R2G

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Cardiotin

Epitope Species: chicken

Product Reactivity/Detection: Cardiotin

Species Reactivity/Detection: mouse, rat, human, porcine, Xenopus, avian, feline, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cardiotin Antibody (R2G): N/A