CAPS1 Antibody (6D8): sc-134298

CAPS1 Antibody (6D8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CAPS1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CAPS1 antibody (6D8) is available as a non-conjugated format. CAPS1, also known as calcyphosine or thyroid protein p24, is a 189 amino acid cytoplasmic protein characterized by four EF-hand domains, which are critical for calcium binding. CAPS1 was initially identified in canine thyroid tissue, and shows significantly lower abundance in humans compared to canines. CAPS1 plays a role in regulating ionic transport and may facilitate cross-signaling between cyclic adenosine monophosphate (cAMP) and calcium-phosphatidylinositol signaling pathways, which are essential for various cellular processes. CAPS1 is expressed in several tissues, including brain, salivary glands, and lungs, with expression levels notably increased in endometrial cancer. This elevated expression suggests CAPS1 could serve as a valuable prognostic marker for patient survival, highlighting potential significance in cancer research and therapeutic strategies.

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CAPS1 Antibody (6D8) References:

1. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach.  |  Li, Z., et al. 2008. Int J Cancer. 123: 2377-83. PMID: 18729184
2. Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family.  |  Dong, H., et al. 2008. J Mol Biol. 383: 455-64. PMID: 18775726
3. Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid.  |  Lefort, A., et al. 1989. EMBO J. 8: 111-6. PMID: 2540953
4. Rapid purification and identification of calcyphosine, a Ca(2+)-binding protein phosphorylated by protein kinase A.  |  Lecocq, R., et al. 1995. Biochem J. 306 (Pt 1): 147-51. PMID: 7864802
5. Loss of calcyphosine gene expression in mouse and other rodents.  |  Clément, S., et al. 1997. Biochem Biophys Res Commun. 232: 407-13. PMID: 9125191
6. Cloning and sequence analysis of human calcyphosine complementary DNA.  |  El Housni, H., et al. 1997. Biochim Biophys Acta. 1352: 249-52. PMID: 9224948
7. Production of dog calcyphosine in bacteria and lack of phosphorylation by the catalytic subunit of protein kinase A in vitro.  |  El Housni, H., et al. 1997. Mol Cell Endocrinol. 135: 93-7. PMID: 9453244
8. Calcium binding protein calcyphosine in dog central astrocytes and ependymal cells and in peripheral neurons.  |  Halleux, P., et al. 1998. J Chem Neuroanat. 15: 239-50. PMID: 9860089

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CAPS1 Antibody (6D8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CAPS1 Antibody (6D8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CAPS1 Antibody (6D8) Specifications

Alternate Product Name: CAPS1

Product Clone Name: 6D8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-110

Epitope Target: CAPS1

Epitope Species: human

Product Reactivity/Detection: CAPS1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CAPS1 Antibody (6D8): N/A