CAP2 Antibody (A-5): sc-377471
- CAP2 Antibody (A-5) is a mouse monoclonal IgG1 κ CAP2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 77-121 mapping near the N-terminus of CAP2 of human origin
- CAP2 Antibody (A-5) is recommended for detection of CAP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CAP2 Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for CAP2 Antibody (A-5) for WB applications. This reagent is now offered in a bundle with CAP2 Antibody (A-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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CAP2 Antibody (A-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CAP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CAP2 (A-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cyclase-associated proteins (CAPs) are evolutionarily conserved proteins that play crucial roles in signal transduction and actin cytoskeleton regulation. CAP2, along with CAP1, is primarily localized to the cell membrane and contains a C-CAP/cofactor C-like domain, essential for function. CAP2 localization allows direct interaction with actin filaments, influencing cellular processes such as motility and morphology. CAP2 is predominantly expressed in skin, brain, heart, and skeletal muscle, and CAP2 overexpression has been linked to hepatocellular carcinoma, indicating a potential role in cancer development. CAP2′s interaction with actin and specific tissue distribution underscores importance in maintaining cellular integrity and function, making anti-CAP2 antibody (A-5) a valuable tool for researchers studying cytoskeletal dynamics and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CAP2 Antibody (A-5) References:
- Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. | Moriyama, K. and Yahara, I. 2002. J Cell Sci. 115: 1591-601. PMID: 11950878
- Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins. | Matviw, H., et al. 1992. Mol Cell Biol. 12: 5033-40. PMID: 1406678
- Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. | Bertling, E., et al. 2004. Mol Biol Cell. 15: 2324-34. PMID: 15004221
- Crystal structure of the actin binding domain of the cyclase-associated protein. | Dodatko, T., et al. 2004. Biochemistry. 43: 10628-41. PMID: 15311924
- Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. | Shibata, R., et al. 2006. Clin Cancer Res. 12: 5363-8. PMID: 17000669
- CAP2, cyclase-associated protein 2, is a dual compartment protein. | Peche, V., et al. 2007. Cell Mol Life Sci. 64: 2702-15. PMID: 17805484
- Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. | Yu, G., et al. 1994. J Cell Sci. 107 (Pt 6): 1671-8. PMID: 7962207
- Mammalian CAP interacts with CAP, CAP2, and actin. | Hubberstey, A., et al. 1996. J Cell Biochem. 61: 459-66. PMID: 8761950
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAP2 Antibody (A-5) | sc-377471 | 200 µg/ml | $316.00 | |||
CAP2 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-523341 | 200 µg Ab, 40 µg BP | $354.00 | |||
CAP2 Antibody (A-5) AC | sc-377471 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CAP2 Antibody (A-5) HRP | sc-377471 HRP | 200 µg/ml | $316.00 | |||
CAP2 Antibody (A-5) FITC | sc-377471 FITC | 200 µg/ml | $330.00 | |||
CAP2 Antibody (A-5) PE | sc-377471 PE | 200 µg/ml | $343.00 | |||
CAP2 Antibody (A-5) Alexa Fluor® 488 | sc-377471 AF488 | 200 µg/ml | $357.00 | |||
CAP2 Antibody (A-5) Alexa Fluor® 546 | sc-377471 AF546 | 200 µg/ml | $357.00 | |||
CAP2 Antibody (A-5) Alexa Fluor® 594 | sc-377471 AF594 | 200 µg/ml | $357.00 | |||
CAP2 Antibody (A-5) Alexa Fluor® 647 | sc-377471 AF647 | 200 µg/ml | $357.00 | |||
CAP2 Antibody (A-5) Alexa Fluor® 680 | sc-377471 AF680 | 200 µg/ml | $357.00 | |||
CAP2 Antibody (A-5) Alexa Fluor® 790 | sc-377471 AF790 | 200 µg/ml | $357.00 |