CAP1 Antibody (M-30): sc-100917
- CAP1 Antibody (M-30) is a mouse monoclonal mouse IgG1 κ κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant CAP1 of human origin
- recommended for detection of CAP1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CAP1 Antibody (M-30). This work is in progress.
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CAP1 Antibody (M-30) is a mouse monoclonal IgG1 antibody that detects cyclase-associated protein 1 (CAP1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CAP1 plays a crucial role in the regulation of actin filaments, which are essential for maintaining cell shape, enabling cellular movement, and facilitating intracellular transport. By mediating processes such as the establishment of cell polarity and mRNA localization, CAP1 is vital for proper cellular function and organization. CAP1′s localization to the cell membrane allows effective interaction with the actin cytoskeleton, influencing various signaling pathways critical for cell growth and differentiation. Notably, CAP1 is expressed throughout the body, highlighting CAP1′s importance in diverse physiological processes. Anti-CAP1 antibody (M-30) serves as an invaluable tool for researchers investigating CAP1′s intricate roles in cellular dynamics and potential implications in diseases where actin regulation is disrupted.
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CAP1 Antibody (M-30) References:
- Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion. | Zhang, H., et al. 2013. J Biol Chem. 288: 20966-20977. PMID: 23737525
- CAP1 (Cyclase-Associated Protein 1) Exerts Distinct Functions in the Proliferation and Metastatic Potential of Breast Cancer Cells Mediated by ERK. | Zhang, H. and Zhou, GL. 2016. Sci Rep. 6: 25933. PMID: 27173014
- Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells. | Quinn, SN., et al. 2017. Mol Carcinog. 56: 1344-1360. PMID: 27891679
- Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase. | Zhang, X., et al. 2018. J Biol Chem. 293: 7659-7673. PMID: 29618512
- Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells. | Wu, H., et al. 2019. Sci Rep. 9: 4925. PMID: 30894654
- Resistin induces breast cancer cells epithelial to mesenchymal transition (EMT) and stemness through both adenylyl cyclase-associated protein 1 (CAP1)-dependent and CAP1-independent mechanisms. | Avtanski, D., et al. 2019. Cytokine. 120: 155-164. PMID: 31085453
- The Cytoskeletal Protein Cyclase-Associated Protein 1 (CAP1) in Breast Cancer: Context-Dependent Roles in Both the Invasiveness and Proliferation of Cancer Cells and Underlying Cell Signals. | Hasan, R. and Zhou, GL. 2019. Int J Mol Sci. 20: PMID: 31151140
- Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. | Schneider, F., et al. 2021. Prog Neurobiol. 202: 102050. PMID: 33845164
- Chromenopyrimidinone exhibit antitumor effects through inhibition of CAP1 (Adenylyl cyclase-associated protein 1) expression in hepatocellular carcinoma. | Kim, N., et al. 2022. Chem Biol Interact. 365: 110066. PMID: 35931200
- Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity. | Heinze, A. and Rust, MB. 2023. Eur J Cell Biol. 102: 151357. PMID: 37634312
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAP1 Antibody (M-30) | sc-100917 | 100 µg/ml | $339.00 |