cAMP Antibody (AM01): sc-73761

cAMP Antibody (AM01) is a mouse monoclonal IgG1 antibody that detects cyclic adenosine monophosphate (cAMP) by immunofluorescence (IF). Anti-cAMP antibody (AM01) is available as a non-conjugated format. cAMP is a crucial second messenger in various signal transduction pathways, playing a vital role in mediating the effects of numerous hormones such as ACTH, glucagon, and epinephrine. cAMP is synthesized from ATP through the action of adenylate cyclase, which is activated upon ligand binding to G protein-coupled receptors. An increase in cAMP concentration leads to the activation of cAMP-dependent protein kinase, which subsequently phosphorylates target proteins, thereby amplifying the cellular signal and influencing a range of physiological processes, including calcium transport, gene activation, and responses related to growth, differentiation, and neurotransmission. Regulation of cAMP levels is equally important, as degradation is managed by phosphodiesterases, ensuring that cellular responses are appropriately modulated. Understanding cAMP dynamics and interactions is essential for elucidating roles in health and disease, making cAMP monoclonal antibody (AM01) a valuable tool for researchers studying these critical signaling pathways.

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cAMP Antibody (AM01) References:

1. Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil.  |  Cronstein, BN., et al. 1992. Blood. 80: 1052-7. PMID: 1323344
2. Cyclic adenosine monophosphate in acute myocardial infarction with heart failure: slayer or savior?  |  Leineweber, K., et al. 2006. Circulation. 114: 365-7. PMID: 16880340
3. Cyclic AMP signalling pathways in the regulation of uterine relaxation.  |  Yuan, W. and López Bernal, A. 2007. BMC Pregnancy Childbirth. 7 Suppl 1: S10. PMID: 17570154
4. New insights into the regulation of cAMP synthesis beyond GPCR/G protein activation: implications in cardiovascular regulation.  |  Feldman, RD. and Gros, R. 2007. Life Sci. 81: 267-71. PMID: 17604058
5. Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats.  |  Yao, W., et al. 2007. J Musculoskelet Neuronal Interact. 7: 119-30. PMID: 17627081
6. Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.  |  De Felice, FG., et al. 2007. Curr Alzheimer Res. 4: 263-71. PMID: 17627483
7. Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells.  |  Omura, M., et al. 2007. Endocr J. 54: 585-92. PMID: 17634670
8. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter.  |  Yuan, W., et al. 2007. J Biol Chem. 282: 29821-30. PMID: 17690094
9. A family of cAMP-binding proteins that directly activate Rap1.  |  Kawasaki, H., et al. 1998. Science. 282: 2275-9. PMID: 9856955

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cAMP Antibody (AM01) has 5 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cAMP Antibody (AM01) Specifications

Alternate Product Name: cAMP

Product Clone Name: AM01

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: cAMP

Epitope Species: N/A

Product Reactivity/Detection: cAMP

Species Reactivity/Detection: N/A

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for cAMP Antibody (AM01): N/A