CAMK2A/CaMKII alpha Antibody (B-2): sc-55508

CaMKIIα Antibody (B-2) is a mouse monoclonal IgG3 antibody that detects CaMKIIα in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CaMKIIα is a critical serine/threonine protein kinase that plays a pivotal role in calcium signaling pathways, particularly in neurons and cardiac tissues, where CaMKIIα is essential for synaptic plasticity and memory formation. CaMKIIα is primarily located in the cytoplasm and can translocate to the nucleus upon activation, which is crucial for function in regulating gene expression and cellular responses to calcium fluctuations. CaMKIIα′s ability to integrate calcium signals and modulate downstream effects underscores importance in various physiological processes, including learning, memory, and muscle contraction. Additionally, CaMKIIα undergoes several post-translational modifications, such as phosphorylation and autophosphorylation, which enhance activity and stability, further emphasizing role in cellular signaling networks. With broad reactivity and proven applications, anti-CaMKIIα antibody (B-2) is an invaluable tool for researchers studying calcium-dependent signaling mechanisms in diverse biological contexts.

The preferred p-CaMKII antibody is p-CaMKII Antibody (22B1): sc-32289.