CAMK2A/CaMKII alpha Antibody (6G9): sc-32288

CaMKIIα Antibody (6G9) is a mouse monoclonal IgG1 kappa light chain antibody that detects CaMKIIα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CaMKIIα antibody (6G9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CaMKIIα plays a crucial role in cellular signaling pathways, particularly in regulating synaptic plasticity and memory formation in neurons, making CaMKIIα essential for cognitive functions. CaMKIIα is primarily located in the cytoplasm and can translocate to the nucleus upon activation, which is vital for modulating gene expression and influencing cellular responses to calcium signaling. CaMKIIα′s presence in both the cytoplasm and nucleus underscores its importance in various physiological processes, including learning and memory, as well as its involvement in pathological conditions such as neurodegenerative diseases. CaMKIIα monoclonal antibody (6G9) enables researchers to gain insights into the functional dynamics of this critical protein and its implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CAMK2A/CaMKII alpha Antibody (6G9) References:

1. Comparison of visual and measured train-of-four recovery after vecuronium-induced neuromuscular blockade using two anaesthetic techniques.  |  O'Hara, DA., et al. 1986. Br J Anaesth. 58: 1300-2. PMID: 2877683
2. Non-canonical Wnt induces chondrocyte de-differentiation through Frizzled 6 and DVL-2/B-raf/CaMKIIα/syndecan 4 axis.  |  Xie, Z., et al. 2018. Cell Death Differ. 25: 1442-1456. PMID: 29352270
3. TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc.  |  Liu, J., et al. 2022. Mol Psychiatry. 27: 2136-2145. PMID: 35079125
4. Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice.  |  Wang, H., et al. 2022. Transl Psychiatry. 12: 380. PMID: 36088395
5. Nano C60 Promotes Synaptic Distribution of Phosphorylated CaMKIIα and Improves Cognitive Function in APP/PS1 Transgenic Mice.  |  Dai, W., et al. 2022. ACS Chem Neurosci. 13: 3534-3543. PMID: 36441865
6. Antidepressant effects of repeated s-ketamine administration as NMDAR Antagonist: Involvement of CaMKIIα and mTOR signaling in the hippocampus of CUMS mice.  |  Liu, B., et al. 2023. Brain Res. 1811: 148375. PMID: 37146745
7. CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice.  |  Ma, Y., et al. 2023. Front Neural Circuits. 17: 1197541. PMID: 37469833
8. Projections from anteromedial thalamus nucleus to the midcingulate cortex mediate pain and anxiety-like behaviors in mice.  |  Hong, J., et al. 2023. Neurochem Int. 171: 105640. PMID: 37951541
9. Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.  |  Gonzalo-Consuegra, C., et al. 2024. Biomed Pharmacother. 174: 116473. PMID: 38522237

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CAMK2A/CaMKII alpha Antibody (6G9) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-CAMK2A/CaMKII alpha Antibody (6G9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CAMK2A/CaMKII alpha Antibody (6G9) Specifications

Alternate Product Name: CAMK2A

Product Clone Name: 6G9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CaMKIIα

Epitope Species: rat

Product Reactivity/Detection: CaMKIIα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for CAMK2A/CaMKII alpha Antibody (6G9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p-CaMKII antibody is p-CaMKII Antibody (22B1): sc-32289.