Calumenin Antibody (F-8): sc-271357

Calumenin Antibody (F-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Calumenin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Calumenin (F-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Calumenin, a 315 amino acid protein, is a member of the CREC, EF-hand protein family and is characterized by six calcium-binding EF-hand motifs. Calumenin is primarily located in the lumen of the endoplasmic reticulum and Golgi apparatus, where Calumenin plays a crucial role in calcium homeostasis and protein folding. Calumenin′s localization facilitates proper functioning of the secretory pathway, ensuring proteins are correctly modified and folded before transport to their final destinations. Calumenin interacts with serum amyloid P component (SAP) in the presence of calcium, suggesting a potential role in immunological defense and pathological processes associated with amyloidosis. Calumenin has been shown to inhibit vitamin K-dependent gamma-carboxylation system, which is essential for activation of several coagulation factors, indicating involvement in thrombosis and wound healing processes.

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Calumenin Antibody (F-8) References:

1. Human calumenin localizes to the secretory pathway and is secreted to the medium.  |  Vorum, H., et al. 1999. Exp Cell Res. 248: 473-81. PMID: 10222138
2. Calumenin interacts with serum amyloid P component.  |  Vorum, H., et al. 2000. FEBS Lett. 465: 129-34. PMID: 10631319
3. Characterization of isoforms and genomic organization of mouse calumenin.  |  Jung, DH. and Kim, DH. 2004. Gene. 327: 185-94. PMID: 14980715
4. The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system. Characterization of the system in normal and warfarin-resistant rats.  |  Wajih, N., et al. 2004. J Biol Chem. 279: 25276-83. PMID: 15075329
5. Proteomics analysis of human astrocytes expressing the HIV protein Tat.  |  Pocernich, CB., et al. 2005. Brain Res Mol Brain Res. 133: 307-16. PMID: 15710248
6. Confirmation of the mapping of the porcine calumenin gene (CALU) to chromosome 18.  |  Kollers, S., et al. 2005. Anim Genet. 36: 177-8. PMID: 15771739
7. The cellular response to ectopic overexpression of the tuberous sclerosis genes, TSC1 and TSC2: a proteomic approach.  |  Hengstschläger, M., et al. 2005. Int J Oncol. 27: 831-8. PMID: 16077935
8. Calumenin, a multiple EF-hands Ca2+-binding protein, interacts with ryanodine receptor-1 in rabbit skeletal sarcoplasmic reticulum.  |  Jung, DH., et al. 2006. Biochem Biophys Res Commun. 343: 34-42. PMID: 16527250
9. Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis.  |  Wang, Q., et al. 2015. Oncogene. 34: 1006-18. PMID: 24632605
10. CALU polymorphism A29809G affects calumenin availability involving vascular calcification.  |  Jover, E., et al. 2015. J Mol Cell Cardiol. 82: 218-27. PMID: 25823396
11. Calumenin relieves cardiac injury by inhibiting ERS-initiated apoptosis during viral myocarditis.  |  Wang, Y., et al. 2017. Int J Clin Exp Pathol. 10: 7277-7284. PMID: 31966567
12. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.  |  Yabe, D., et al. 1997. J Biol Chem. 272: 18232-9. PMID: 9218460

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Calumenin Antibody (F-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Calumenin Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Calumenin Antibody (F-8) Specifications

Alternate Product Name: Calumenin

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 89-128

Epitope Target: Calumenin

Epitope Species: human

Product Reactivity/Detection: Calumenin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Calumenin Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin