Calpain 15 Antibody (D-5): sc-514406
- Calpain 15 Antibody (D-5) is a mouse monoclonal IgG1 κ Calpain 15 antibody provided at 200 µg/ml
- raised against amino acids 1-119 mapping at the N-terminus of Calpain 15 of human origin
- Calpain 15 Antibody (D-5) is recommended for detection of Calpain 15 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Calpain 15 Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Calpain 15 Antibody (D-5) for WB applications. This reagent is now offered in a bundle with Calpain 15 Antibody (D-5) (see ordering information below).
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Calpain 15 Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Calpain 15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Calpain 15 antibody (D-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Calpain 15, also known as CAPN15 or SOLH (small optic lobes homolog), is a crucial protein that plays a significant role in cellular processes, particularly in the brain where CAPN15 is most abundantly expressed. CAPN15 is a member of the peptidase C2 family and is characterized by a unique structure, which includes a single calpain catalytic domain and five RanBP2-type zinc fingers. These zinc fingers facilitate protein-protein interactions, which are essential for CAPN15′s function as an RNA-binding protein and transcription factor. CAPN15 is involved in the development of the visual system, highlighting CAPN15′s importance in neurodevelopmental processes. Located on human chromosome 16, CAPN15 exists in two alternatively spliced isoforms, further underscoring the complexity and versatility of CAPN15′s biological roles.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Calpain 15 Antibody (D-5) References:
- Revisiting ubiquity and tissue specificity of human calpains. | Farkas, A., et al. 2003. Biol Chem. 384: 945-9. PMID: 12887062
- Spectrin and calpain: a 'target' and a 'sniper' in the pathology of neuronal cells. | Czogalla, A. and Sikorski, AF. 2005. Cell Mol Life Sci. 62: 1913-24. PMID: 15990959
- The calpains: modular designs and functional diversity. | Croall, DE. and Ersfeld, K. 2007. Genome Biol. 8: 218. PMID: 17608959
- Emerging functions of the calpain superfamily of cysteine proteases in neuroendocrine secretory pathways. | Evans, JS. and Turner, MD. 2007. J Neurochem. 103: 849-59. PMID: 17666040
- Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching. | Banfi, S., et al. 1996. Nat Genet. 13: 167-74. PMID: 8640222
- SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia). | Kamei, M., et al. 1998. Genomics. 51: 197-206. PMID: 9722942
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain 15 Antibody (D-5) | sc-514406 | 200 µg/ml | $316.00 | |||
Calpain 15 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-526366 | 200 µg Ab; 10 µg BP | $354.00 | |||
Calpain 15 Antibody (D-5) AC | sc-514406 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Calpain 15 Antibody (D-5) HRP | sc-514406 HRP | 200 µg/ml | $316.00 | |||
Calpain 15 Antibody (D-5) FITC | sc-514406 FITC | 200 µg/ml | $330.00 | |||
Calpain 15 Antibody (D-5) PE | sc-514406 PE | 200 µg/ml | $343.00 | |||
Calpain 15 Antibody (D-5) Alexa Fluor® 488 | sc-514406 AF488 | 200 µg/ml | $357.00 | |||
Calpain 15 Antibody (D-5) Alexa Fluor® 546 | sc-514406 AF546 | 200 µg/ml | $357.00 | |||
Calpain 15 Antibody (D-5) Alexa Fluor® 594 | sc-514406 AF594 | 200 µg/ml | $357.00 | |||
Calpain 15 Antibody (D-5) Alexa Fluor® 647 | sc-514406 AF647 | 200 µg/ml | $357.00 | |||
Calpain 15 Antibody (D-5) Alexa Fluor® 680 | sc-514406 AF680 | 200 µg/ml | $357.00 | |||
Calpain 15 Antibody (D-5) Alexa Fluor® 790 | sc-514406 AF790 | 200 µg/ml | $357.00 |