Calpain 11 Antibody (C-10): sc-376213
- Calpain 11 Antibody (C-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-60 mapping at the N-terminus of Calpain 11 of human origin
- recommended for detection of Calpain 11 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Calpain 11 Antibody (C-10) for WB applications. These reagents are now offered in bundles with Calpain 11 Antibody (C-10) (see ordering information below).
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Calpain 11 Antibody (C-10) is a mouse monoclonal IgG1 antibody that detects Calpain 11 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Calpain 11 is a member of the calpain family, which consists of calcium-activated thiol proteases that play a crucial role in intracellular protein processing. Anti-Calpain 11 antibody (C-10) recognizes a unique structure featuring four domains, with a calmodulin-like domain replacing the typical domain IV, allowing association with the smaller regulatory subunit without direct interaction. The structural integrity of Calpain 11 is vital for its function, as Calpain 11 is localized in the testis and specifically found in spermatozoa during the later stages of meiosis. This localization suggests a role in spermatogenesis, potentially regulating calcium-dependent signaling pathways essential for sperm development and functionality. Calpain 11 (C-10) antibody enables researchers to gain insights into calcium signaling mechanisms in reproductive biology and calpain roles in cellular processes.
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Calpain 11 Antibody (C-10) References:
- CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6. | Dear, TN., et al. 1999. Genomics. 59: 243-7. PMID: 10409436
- The calpain system. | Goll, DE., et al. 2003. Physiol Rev. 83: 731-801. PMID: 12843408
- Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer. | Kulkarni, YM. and Klinke, DJ. 2012. Proteome Sci. 10: 11. PMID: 22357162
- Targeting calpain in synaptic plasticity. | Baudry, M., et al. 2013. Expert Opin Ther Targets. 17: 579-92. PMID: 23379852
- The calpain system and diabetes. | Pandurangan, M., et al. 2014. Pathophysiology. 21: 161-7. PMID: 24630865
- Neuroprotective strategies against calpain-mediated neurodegeneration. | Yildiz-Unal, A., et al. 2015. Neuropsychiatr Dis Treat. 11: 297-310. PMID: 25709452
- Regulatory role of calpain in neuronal death. | Cheng, SY., et al. 2018. Neural Regen Res. 13: 556-562. PMID: 29623944
- Calpain-calpastatin system and cancer progression. | Nian, H. and Ma, B. 2021. Biol Rev Camb Philos Soc. 96: 961-975. PMID: 33470511
- Calpain Inhibitors as Potential Therapeutic Modulators in Neurodegenerative Diseases. | Khan, H., et al. 2022. Neurochem Res. 47: 1125-1149. PMID: 34982393
- Calpain-mediated Mechanoptosis in Breast Adenocarcinoma. | Metaxas, GI., et al. 2023. Cancer Diagn Progn. 3: 297-301. PMID: 37168957
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain 11 Antibody (C-10) | sc-376213 | 200 µg/ml | $316.00 | |||
Calpain 11 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-540528 | 200 µg Ab; 10 µg BP | $354.00 | |||
Calpain 11 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-542184 | 200 µg Ab; 20 µg BP | $354.00 |