Calpain 1 Antibody (A-5): sc-390677
- Calpain 1 Antibody (A-5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 682-709 of Calpain 1 catalytic subunit of human origin
- recommended for detection of Calpain 1 catalytic subunit of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See Calpain 1 (D-11): sc-271313 for Calpain 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Calpain 1 Antibody (A-5) for WB applications. These reagents are now offered in bundles with Calpain 1 Antibody (A-5) (see ordering information below).
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SEE ALSO...
Calpain 1 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects Calpain 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Calpain 1, also known as µ-calpain, is an intracellular calcium-dependent protease that plays a crucial role in various cellular processes by cleaving cytoskeletal and submembranous proteins. This protein is essential for mediating calcium-dependent events such as cell fusion, mitosis, and meiosis, which are vital for normal cellular function and development. The structure of Calpain 1 is characterized by a heterodimeric composition, consisting of a small regulatory subunit and a large catalytic subunit, which allows for precise regulation of proteolytic activity. Regulation of Calpain 1 is further influenced by calpastatin, a specific inhibitor that modulates activity and membrane binding, highlighting the importance of post-translational modifications in controlling function. Notably, Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain, suggesting involvement in neuroinflammatory processes. Additionally, Calpain 1 is critical in spermatogenesis and the acrosome reaction, underscoring significance in reproductive biology. With versatile applications and essential biological roles, anti-Calpain 1 antibody (A-5) serves as an invaluable tool for researchers studying cellular dynamics and signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain 1 Antibody (A-5) | sc-390677 | 200 µg/ml | $322.00 | |||
Calpain 1 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-540832 | 200 µg Ab; 10 µg BP | $361.00 | |||
Calpain 1 Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-542401 | 200 µg Ab; 20 µg BP | $361.00 | |||
Calpain 1 (A-5) Neutralizing Peptide | sc-390677 P | 100 µg/0.5 ml | $69.00 |