Calcitriol Antibody (B1253M): sc-73623

Calcitriol Antibody (B1253M) is a mouse monoclonal IgG antibody that detects Calcitriol in non-species reactive applications such as enzyme-linked immunosorbent assay (ELISA). Anti-Calcitriol antibody (B1253M) is available in a non-conjugated form, allowing for versatile use in various experimental setups. Calcitriol, also known as 1,25-dihydroxyvitamin D3 or 1,25(OH)2 vitamin D3, is the biologically active form of vitamin D, synthesized in the kidneys from Calcidiol through the action of the enzyme 1α-hydroxylase. This steroid hormone maintains calcium and phosphate balance in the body by binding to the vitamin D receptor (VDR) and regulating the transcription of genes involved in calcium absorption and bone metabolism. Calcitriol enhances intestinal absorption of calcium and phosphate, promotes resorption of these minerals from bone, and facilitates reabsorption in the kidneys, playing a vital role in bone mineralization and skeletal health. Calcitriol also modulates immune responses and influences cellular processes such as proliferation and differentiation, highlighting its importance in both metabolic and immune functions.

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Calcitriol Antibody (B1253M) References:

1. 1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization.  |  Healy, KD., et al. 2005. Arch Biochem Biophys. 433: 466-73. PMID: 15581603
2. 1,25-Dihydroxy vitamin D3: can it be an effective therapeutic option for aggressive fibromatosis.  |  Yildiz, F., et al. 2005. Med Hypotheses. 64: 333-6. PMID: 15607567
3. 1,25-dihydroxyvitamin D3 stimulates vesicular transport within 5 s in polarized intestinal epithelial cells.  |  Sterling, TM. and Nemere, I. 2005. J Endocrinol. 185: 81-91. PMID: 15817829
4. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts.  |  van Etten, E. and Mathieu, C. 2005. J Steroid Biochem Mol Biol. 97: 93-101. PMID: 16046118
5. Calcitriol sensitizes colon cancer cells to H2O2-induced cytotoxicity while inhibiting caspase activation.  |  Koren, R., et al. 2006. J Steroid Biochem Mol Biol. 101: 151-60. PMID: 16889957
6. Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3).  |  Jones, G. 2007. Semin Dial. 20: 316-24. PMID: 17635821
7. Effects of active vitamin D3 and parathyroid hormone on the serum osteocalcin in idiopathic hypoparathyroidism and pseudohypoparathyroidism.  |  Mizunashi, K., et al. 1988. J Clin Invest. 82: 861-5. PMID: 2843573
8. Differentiation of a human monocytic cell line by 1,25-dihydroxyvitamin D3 (calcitriol): a morphologic, phenotypic, and functional analysis.  |  Rigby, WF., et al. 1984. Blood. 64: 1110-5. PMID: 6548394
9. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed.  |  Haussler, MR., et al. 1998. J Bone Miner Res. 13: 325-49. PMID: 9525333

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Calcitriol Antibody (B1253M) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Calcitriol Antibody (B1253M) Specifications

Alternate Product Name: Calcitriol

Product Clone Name: B1253M

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Calcitriol

Epitope Species:

Product Reactivity/Detection: Calcitriol

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of TBS with < 0.1% sodium azide, 0.1% gelatin and < 0.1% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Calcitriol Antibody (B1253M): N/A