Calcitonin Antibody (16B5): sc-51798

Calcitonin Antibody (16B5) is a mouse monoclonal IgG2b kappa light chain antibody that detects calcitonin in human samples through western blotting (WB) and immunoprecipitation (IP). Anti-calcitonin antibody (16B5) is available in a non-conjugated form, specifically designed for researchers seeking to study calcitonin′s role in various physiological processes. Calcitonin is a 32-amino acid polypeptide hormone primarily produced in the thyroid gland, where calcitonin plays a crucial role in maintaining skeletal integrity and regulating calcium homeostasis. By inhibiting osteoclast activity, calcitonin effectively reduces blood calcium levels, which is vital for preventing hypercalcemia and ensuring proper bone health. Additionally, calcitonin influences renal function by decreasing calcium and phosphate reabsorption in kidney tubules and modulating calcium absorption in the intestines. The regulation of calcitonin secretion is intricately linked to hormonal signals, particularly estrogen, which enhances calcitonin mRNA levels. The calcitonin gene, CALCA, is notable for tissue-specific alternative splicing, leading to the production of various mRNA transcripts, including those encoding procalcitonin and the neuropeptide calcitonin gene-related peptide (CGRP). Understanding the dynamics of calcitonin and its interactions with other proteins is essential for elucidating calcitonin′s multifaceted roles in health and disease, making calcitonin monoclonal antibody (16B5) an invaluable tool for researchers in the field.

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Calcitonin Antibody (16B5) References:

1. Measurement of calcitonin by immunoassay analyzers.  |  Bieglmayer, C., et al. 2007. Clin Chem Lab Med. 45: 662-6. PMID: 17484631
2. Skeletal effects of calcitonin in ovariectomized rats.  |  Wronski, TJ., et al. 1991. Endocrinology. 129: 2246-50. PMID: 1915104
3. Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis.  |  Kauther, MD., et al. 2011. BMC Musculoskelet Disord. 12: 186. PMID: 21843355
4. The second human calcitonin/CGRP gene is located on chromosome 11.  |  Höppener, JW., et al. 1985. Hum Genet. 70: 259-63. PMID: 2991116
5. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide.  |  Amara, SG., et al. 1985. Science. 229: 1094-7. PMID: 2994212
6. The complete sequence of human preprocalcitonin.  |  Le Moullec, JM., et al. 1984. FEBS Lett. 167: 93-7. PMID: 6546550
7. Calcitonin gene regulation in vivo.  |  Silver, J. and Naveh-Many, T. 1993. Horm Metab Res. 25: 470-2. PMID: 8225199
8. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members.  |  Hoovers, JM., et al. 1993. Genomics. 15: 525-9. PMID: 8468047
9. Calcitonin mRNA is produced in liver by two different splicing pathways.  |  Bracq, S., et al. 1997. Mol Cell Endocrinol. 128: 111-5. PMID: 9140082
10. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.  |  Wimalawansa, SJ. 1997. Crit Rev Neurobiol. 11: 167-239. PMID: 9209829
11. Heterogeneity of circulating calcitonin levels: relations with calcitonin biosynthesis in medullary thyroid carcinomas.  |  Guliana, JM., et al. 1994. Nucl Med Biol. 21: 359-68. PMID: 9234301
12. Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide.  |  Lou, H. and Gagel, RF. 1998. J Endocrinol. 156: 401-5. PMID: 9582495

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Calcitonin Antibody (16B5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Calcitonin Antibody (16B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Calcitonin Antibody (16B5) Specifications

Alternate Product Name: Calcitonin

Product Clone Name: 16B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Calcitonin

Epitope Species: human

Product Reactivity/Detection: calcitonin and procalcitonin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Calcitonin Antibody (16B5): N/A

The preferred CGRP antibody is CGRP Antibody (4901): sc-57053.