CGRP Antibody (4901): sc-57053

CGRP Antibody (4901) is a mouse monoclonal IgG1 kappa light chain antibody that detects CGRP in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CGRP (4901) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Calcitonin Gene-Related Peptide (CGRP) is a 37-amino acid neuropeptide that plays a crucial role in vasodilation and pain pathway modulation, making CGRP significant in migraine and other vascular disorders. CGRP (4901) monoclonal antibody detects this neuropeptide primarily in the central and peripheral nervous systems, where CGRP is synthesized and released from sensory neurons. CGRP presence in these locations is vital for mediating neurogenic inflammation and regulating blood flow, particularly in conditions such as migraine, where CGRP levels are often elevated. The CGRP gene, CALCA, undergoes alternative splicing to produce different isoforms, including CGRP1 and CGRP2, which exhibit distinct biological activities. Understanding CGRP localization and function is essential for developing targeted therapies for migraine and other related conditions, highlighting anti-CGRP antibody (4901) significance in research and clinical applications.

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CGRP Antibody (4901) References:

1. Skeletal effects of calcitonin in ovariectomized rats.  |  Wronski, TJ., et al. 1991. Endocrinology. 129: 2246-50. PMID: 1915104
2. The second human calcitonin/CGRP gene is located on chromosome 11.  |  Höppener, JW., et al. 1985. Hum Genet. 70: 259-63. PMID: 2991116
3. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide.  |  Amara, SG., et al. 1985. Science. 229: 1094-7. PMID: 2994212
4. Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting.  |  Wattiez, AS., et al. 2020. Expert Opin Ther Targets. 24: 91-100. PMID: 32003253
5. Pharmacokinetics, Pharmacodynamics and Drug-Drug Interactions of New Anti-Migraine Drugs-Lasmiditan, Gepants, and Calcitonin-Gene-Related Peptide (CGRP) Receptor Monoclonal Antibodies.  |  Szkutnik-Fiedler, D. 2020. Pharmaceutics. 12: PMID: 33287305
6. Depression and treatment with anti-calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies for migraine.  |  de Vries Lentsch, S., et al. 2024. Eur J Neurol. 31: e16106. PMID: 37847221
7. The complete sequence of human preprocalcitonin.  |  Le Moullec, JM., et al. 1984. FEBS Lett. 167: 93-7. PMID: 6546550
8. Calcitonin gene regulation in vivo.  |  Silver, J. and Naveh-Many, T. 1993. Horm Metab Res. 25: 470-2. PMID: 8225199
9. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members.  |  Hoovers, JM., et al. 1993. Genomics. 15: 525-9. PMID: 8468047
10. Calcitonin mRNA is produced in liver by two different splicing pathways.  |  Bracq, S., et al. 1997. Mol Cell Endocrinol. 128: 111-5. PMID: 9140082
11. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.  |  Wimalawansa, SJ. 1997. Crit Rev Neurobiol. 11: 167-239. PMID: 9209829
12. Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide.  |  Lou, H. and Gagel, RF. 1998. J Endocrinol. 156: 401-5. PMID: 9582495

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CGRP Antibody (4901) has 57 citations in a variety of scientific publications.

Primary antibodies like Anti-CGRP Antibody (4901) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CGRP Antibody (4901) Specifications

Alternate Product Name: Calcitonin Gene-Related Peptide

Product Clone Name: 4901

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CGRP1

Epitope Species: rat

Product Reactivity/Detection: CGRP1 and CGRP2

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 57 citations in various scientific publications

Available Conjugates/Forms for CGRP Antibody (4901): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin