Calcitonin Antibody (13f2): sc-51794
- Calcitonin Antibody (13f2) is a mouse monoclonal IgG1 Calcitonin antibody provided at 100 µg/ml
- raised against a purified human calcitonin fragment
- recommended for detection of calcitonin of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Calcitonin Antibody (13f2). This work is in progress.
QUICK LINKS
SEE ALSO...
Calcitonin Antibody (13f2) is a mouse monoclonal IgG1 antibody that detects the Calcitonin protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Calcitonin antibody (13f2) is available as a non-conjugated format. Calcitonin is a 32 amino acid polypeptide hormone that plays a crucial role in maintaining skeletal integrity and regulating calcium homeostasis by inhibiting osteoclast activity in bones, reducing calcium and phosphate reabsorption in kidney tubules, and decreasing calcium absorption in the intestines. The regulation of Calcitonin secretion from the thyroid is influenced by estrogen, which enhances Calcitonin mRNA levels. The CALCA gene, which encodes Calcitonin, undergoes tissue-specific RNA alternative splicing, leading to the production of various mRNA transcripts, including procalcitonin and the active polypeptides Calcitonin and katacalcin. Additionally, an alternative transcript of CALCA encodes the precursor for the neuropeptide Calcitonin gene-related peptide 1, also known as CGRP1 or α-CGRP, which is a widely distributed vasodilatory peptide. While Calcitonin and katacalcin are primarily produced in the thyroid, CGRP is synthesized in neuronal cells. Furthermore, a related gene, CALCB, which is believed to have arisen from a gene duplication event, has been identified in mouse, rat, and human, encoding a single transcript known as CGRP2 or β-CGRP. Notably, mature CGRP1 and CGRP2 exhibit significant sequence identity, differing by only 1-3 amino acid residues across species, highlighting the evolutionary conservation of these peptides.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Calcitonin Antibody (13f2) References:
- Calcitonin for metastatic bone pain. | Martinez-Zapata, MJ., et al. 2006. Cochrane Database Syst Rev. 2006: CD003223. PMID: 16856000
- Calcitonin and calcitonin receptors. | Masi, L. and Brandi, ML. 2007. Clin Cases Miner Bone Metab. 4: 117-22. PMID: 22461211
- Nanostructure and stability of calcitonin amyloids. | Rigoldi, F., et al. 2017. J Biol Chem. 292: 7348-7357. PMID: 28283568
- Serotonin, calcitonin and calcitonin gene-related peptide in acute pancreatitis. | Wahlstrøm, KL., et al. 2017. Scand J Gastroenterol. 52: 1140-1147. PMID: 28679347
- Cholecystokininoma syndrome, calcitonin and diarrhea. | Rehfeld, JF., et al. 2017. Scand J Gastroenterol. 52: 1304-1305. PMID: 28738700
- Calcitonin as a pharmacological anchorage in orthodontics. | Pizzo-Reis, PM., et al. 2023. Indian J Dent Res. 34: 14-18. PMID: 37417050
- Calcitonin in pregnancy. | Kovarik, J., et al. 1980. Lancet. 1: 199-200. PMID: 6101649
- Precursor molecule for calcitonin. | van der Donk, JA., et al. 1976. Lancet. 2: 1133. PMID: 62964
- Calcitonin and postmenopausal osteoporosis. | Leggate, J., et al. 1984. Clin Endocrinol (Oxf). 20: 85-92. PMID: 6362926
- Serum calcitonin in hyperthyroidism. | Földes, J., et al. 1983. Acta Med Hung. 40: 99-105. PMID: 6689443
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calcitonin Antibody (13f2) | sc-51794 | 100 µg/ml | $316.00 |